| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $563,369 | -43.9% | 100 | -3 | $5,633 | $23,754,895 | 12 | 20th Century Fox International | false | false |
| 2 | 5 | Shutter Island | $296,313 | -32.8% | 51 | - | $5,810 | $1,525,693 | 3 | Universal Pictures International (UPI) | false | false |
| 3 | - | The Book of Eli | $267,691 | - | 52 | - | $5,147 | $318,303 | 1 | Paradiso Entertainment | true | false |
| 4 | 6 | Valentine's Day | $201,021 | -54.1% | 106 | - | $1,896 | $3,136,073 | 4 | Warner Bros. | false | false |
| 5 | 2 | Cloudy with a Chance of Meatballs | $167,698 | -77.6% | 85 | +2 | $1,972 | $2,066,360 | 3 | Sony Pictures Releasing | false | false |
| 6 | 9 | The Lovely Bones | $160,990 | -49.6% | 54 | - | $2,981 | $557,801 | 2 | Universal Pictures International (UPI) | false | false |
| 7 | 8 | Gangsterboys | $158,158 | -51.7% | 39 | - | $4,055 | $1,119,310 | 3 | Independent Films | false | false |
| 8 | 7 | Percy Jackson & the Olympians: The Lightning Thief | $130,506 | -64.1% | 95 | -1 | $1,373 | $1,805,103 | 4 | Warner Bros. | false | false |
| 9 | 4 | Eep! 2010 Re-release | $123,300 | -75.6% | 88 | +1 | $1,401 | $1,323,932 | 3 | Independent Films | false | false |
| 10 | - | Invictus | $107,077 | - | 27 | - | $3,965 | $120,084 | 1 | Warner Bros. | true | false |
| 11 | 3 | The Princess and the Frog | $104,956 | -80.3% | 117 | -5 | $897 | $2,766,262 | 5 | Walt Disney Pictures | false | false |
| 12 | - | Chloe | $102,567 | - | 39 | - | $2,629 | $104,618 | 1 | Universal Pictures International (UPI) | true | false |
| 13 | 13 | A Single Man | $58,961 | -31.5% | 20 | - | $2,948 | $593,855 | 5 | Cinéart | false | false |
| 14 | 10 | Alvin and the Chipmunks: The Squeakquel | $51,738 | -80.5% | 97 | -9 | $533 | $7,019,915 | 11 | Warner Bros. | false | false |
| 15 | 11 | The Wolfman | $48,764 | -56.2% | 51 | -5 | $956 | $713,685 | 4 | Universal Pictures International (UPI) | false | false |
| 16 | 19 | A Prophet | $41,169 | -20.3% | 26 | +1 | $1,583 | $412,413 | 5 | Cinemien | false | false |
| 17 | 17 | The Girl Who Played with Fire | $33,539 | -40.1% | 28 | -7 | $1,197 | $1,012,398 | 7 | Benelux Film Distributors | false | false |
| 18 | - | The Last Station 2010 Re-release | $30,870 | - | 22 | - | $1,403 | $103,806 | 1 | Entertainment One | true | false |
| 19 | 15 | Love Life | $29,349 | -55.7% | 57 | -10 | $514 | $12,514,413 | 15 | Benelux Film Distributors | false | false |
| 20 | 14 | Edge of Darkness | $27,855 | -60.8% | 36 | -19 | $773 | $1,140,932 | 6 | Entertainment One | false | false |
