| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Alice in Wonderland | $75,635 | - | 4 | - | $18,908 | $75,635 | 1 | Walt Disney Pictures | true | false |
| 2 | 1 | Avatar | $56,048 | -25.1% | 8 | - | $7,006 | $2,055,659 | 12 | 20th Century Fox International | false | false |
| 3 | 3 | My Name Is Khan | $44,049 | +27.5% | 8 | - | $5,506 | $137,019 | 3 | 20th Century Fox International | false | false |
| 4 | 2 | The Wolfman | $31,829 | -37.2% | 9 | - | $3,536 | $88,932 | 2 | United International Pictures | false | false |
| 5 | 4 | Valentine's Day | $21,181 | -27.5% | 5 | - | $4,236 | $199,020 | 4 | Warner Bros. | false | false |
| 6 | 5 | The Book of Eli | $16,505 | -23.8% | 8 | - | $2,063 | $238,356 | 6 | - | false | false |
| 7 | 6 | Percy Jackson & the Olympians: The Lightning Thief | $13,188 | +11.7% | 8 | - | $1,648 | $87,869 | 4 | 20th Century Fox International | false | false |
| 8 | - | The Tournament | $10,098 | - | 5 | - | $2,019 | $10,098 | 1 | - | true | false |
| 9 | 8 | It's Complicated | $8,523 | -19.5% | 6 | - | $1,420 | $99,974 | 5 | United International Pictures | false | false |
| 10 | 7 | Stag Night | $8,103 | -26.2% | 3 | - | $2,701 | $21,648 | 2 | N/A | false | false |
| 11 | 9 | Sherlock Holmes | $6,736 | -30.4% | 5 | - | $1,347 | $386,925 | 10 | Warner Bros. | false | false |
| 12 | 10 | Up in the Air | $6,650 | -22.4% | 5 | - | $1,330 | $60,882 | 4 | United International Pictures | false | false |
| 13 | 11 | Old Dogs | $3,533 | -36.3% | 3 | -1 | $1,177 | $120,878 | 9 | Walt Disney Pictures | false | false |
| 14 | 12 | Alvin and the Chipmunks: The Squeakquel | $2,581 | -47.6% | 3 | - | $860 | $147,014 | 11 | 20th Century Fox International | false | false |
| 15 | 13 | Triangle | $950 | -76.2% | 3 | - | $316 | $60,626 | 5 | N/A | false | false |
| 16 | 14 | The Princess and the Frog | $941 | -72.3% | 2 | - | $470 | $75,053 | 10 | Walt Disney Pictures | false | false |
| 17 | 15 | Did You Hear About the Morgans? | $763 | -75.1% | 1 | -1 | $763 | $60,893 | 6 | Sony Pictures Releasing | false | false |
| 18 | 16 | Nine | $579 | -52% | 3 | - | $193 | $74,162 | 7 | N/A | false | false |
| 19 | 18 | High Lane | $363 | -48.4% | 3 | - | $121 | $21,594 | 6 | N/A | false | false |
| 20 | 17 | 2012 | $286 | -62% | 2 | -1 | $143 | $1,099,578 | 17 | Sony Pictures Releasing | false | false |
| 21 | 20 | The Box | $187 | -32% | 1 | - | $187 | $30,678 | 8 | N/A | false | false |
| 22 | 22 | Cirque du Freak: The Vampire's Assistant | $178 | +23.6% | 2 | - | $89 | $42,000 | 13 | United International Pictures | false | false |
| 23 | 19 | The Ugly Duckling and Me! | $98 | -66.1% | 1 | - | $98 | $5,506 | 5 | N/A | false | false |
