| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 2 | Old Dogs | $234,797 | +6% | 51 | +8 | $4,603 | $1,181,590 | 3 | United International Pictures | false | false |
| 2 | 1 | Percy Jackson & the Olympians: The Lightning Thief | $218,873 | -9.1% | 69 | +15 | $3,172 | $786,900 | 2 | 20th Century Fox International | false | false |
| 3 | 3 | The Wolfman | $130,826 | -18.2% | 58 | +10 | $2,255 | $509,358 | 2 | United International Pictures | false | false |
| 4 | 4 | Valentine's Day | $117,718 | -14.9% | 50 | +6 | $2,354 | $430,897 | 2 | Warner Bros. | false | false |
| 5 | - | Armored | $71,239 | - | 30 | - | $2,374 | $71,239 | 1 | Sony Pictures Releasing | true | false |
| 6 | - | The Lovely Bones | $54,010 | - | 42 | - | $1,285 | $54,010 | 1 | United International Pictures | true | false |
| 7 | 7 | Avatar | $53,279 | -5.7% | 18 | - | $2,959 | $4,983,645 | 10 | 20th Century Fox International | false | false |
| 8 | 5 | Tooth Fairy | $48,039 | -36.5% | 44 | +4 | $1,091 | $1,587,840 | 6 | 20th Century Fox International | false | false |
| 9 | 6 | My Bloody Valentine | $39,605 | -46.3% | 17 | -8 | $2,329 | $208,732 | 2 | N/A | false | false |
| 10 | - | The Hurt Locker | $27,778 | - | 10 | - | $2,777 | $27,778 | 1 | N/A | true | false |
| 11 | 9 | Invictus | $25,588 | -34.6% | 17 | -6 | $1,505 | $246,688 | 3 | Warner Bros. | false | false |
| 12 | 8 | Cirque du Freak: The Vampire's Assistant | $22,634 | -58.8% | 28 | -5 | $808 | $333,884 | 3 | United International Pictures | false | false |
| 13 | 17 | Funny People | $7,623 | +637.2% | 6 | +4 | $1,270 | $104,578 | 4 | United International Pictures | false | false |
| 14 | 11 | Nine | $7,343 | -41.5% | 3 | -1 | $2,447 | $112,411 | 4 | Sony Pictures Releasing | false | false |
| 15 | 15 | Astro Boy | $4,702 | +18.7% | 13 | +3 | $361 | $86,508 | 4 | N/A | false | false |
| 16 | 13 | Zombieland | $2,939 | -49.5% | 9 | -1 | $326 | $194,856 | 4 | Sony Pictures Releasing | false | false |
| 17 | 20 | Unrest 2009 Re-release | $2,902 | +907.6% | 4 | +3 | $725 | $245,088 | 7 | N/A | false | false |
| 18 | 14 | Up in the Air | $2,722 | -38.8% | 6 | - | $453 | $264,463 | 5 | United International Pictures | false | false |
| 19 | 22 | Penelope | $2,266 | +6,024.3% | 5 | +4 | $453 | $49,450 | 4 | N/A | false | false |
| 20 | 12 | The Time Traveler's Wife | $1,425 | -75.8% | 1 | -2 | $1,425 | $46,367 | 3 | N/A | false | false |
| 21 | - | Fantastic Mr. Fox | $785 | - | 1 | - | $785 | $3,415 | 2 | 20th Century Fox International | false | false |
| 22 | 16 | Alvin and the Chipmunks: The Squeakquel | $772 | -79.6% | 4 | -6 | $193 | $1,746,683 | 9 | 20th Century Fox International | false | false |
| 23 | 10 | Sherlock Holmes | $386 | -97.6% | 2 | -14 | $193 | $1,167,737 | 6 | Warner Bros. | false | false |
| 24 | 18 | The Princess and the Frog | $285 | -69.4% | 4 | +3 | $71 | $1,994,439 | 11 | Walt Disney Pictures | false | false |
