| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $33,065 | -28.5% | 7 | - | $4,723 | $1,067,181 | 11 | 20th Century Fox International | false | false |
| 2 | - | Edge of Darkness | $24,354 | - | 7 | - | $3,479 | $24,354 | 1 | Warner Bros. | true | false |
| 3 | - | Did You Hear About the Morgans? | $20,414 | - | 5 | - | $4,082 | $20,414 | 1 | Sony Pictures Releasing | true | false |
| 4 | - | Tooth Fairy | $12,944 | - | 5 | - | $2,588 | $34,688 | 1 | 20th Century Fox International | true | false |
| 5 | 3 | Toy Story 2 2009 Re-release | $10,324 | -42% | 6 | - | $1,720 | $39,504 | 2 | Walt Disney Pictures | false | false |
| 6 | 4 | An Education | $9,728 | -43.5% | 4 | - | $2,432 | $36,105 | 2 | Sony Pictures Releasing | false | false |
| 7 | 2 | Valentine's Day | $8,148 | -60.5% | 6 | -1 | $1,358 | $126,418 | 3 | Warner Bros. | false | false |
| 8 | 5 | Invictus | $8,126 | -43.2% | 7 | - | $1,160 | $199,049 | 6 | Warner Bros. | false | false |
| 9 | 8 | The Wolfman | $6,357 | -39.8% | 5 | - | $1,271 | $50,434 | 3 | Universal Pictures International (UPI) | false | false |
| 10 | 9 | Precious | $4,470 | -43.3% | 4 | - | $1,117 | $34,558 | 3 | N/A | false | false |
| 11 | 14 | The Girl with the Dragon Tattoo | $4,077 | -10.7% | 4 | +1 | $1,019 | $76,673 | 6 | N/A | false | false |
| 12 | 6 | Old Dogs | $3,434 | -71% | 4 | - | $858 | $135,400 | 6 | Walt Disney Pictures | false | false |
| 13 | 11 | It's Complicated | $3,179 | -46.8% | 4 | -1 | $794 | $175,658 | 7 | United International Pictures | false | false |
| 14 | - | A Serious Man | $3,170 | - | 1 | - | $3,170 | $8,101 | 1 | Universal Pictures International (UPI) | true | false |
| 15 | 7 | Percy Jackson & the Olympians: The Lightning Thief | $2,672 | -75.2% | 4 | -1 | $668 | $44,231 | 3 | 20th Century Fox International | false | false |
| 16 | 10 | Sherlock Holmes | $2,544 | -60.9% | 4 | - | $636 | $199,092 | 7 | Warner Bros. | false | false |
| 17 | 15 | Up in the Air | $1,656 | -62.1% | 4 | -1 | $414 | $134,795 | 6 | Paramount Pictures International | false | false |
| 18 | 12 | Alvin and the Chipmunks: The Squeakquel | $1,335 | -77.2% | 3 | -1 | $445 | $166,274 | 9 | 20th Century Fox International | false | false |
| 19 | - | The Girl by the Lake 2009 Re-release | $1,247 | - | 1 | - | $1,247 | $1,247 | 1 | N/A | true | false |
| 20 | 16 | Easy Virtue | $989 | -53.3% | 2 | -2 | $494 | $30,669 | 5 | Sony Pictures Releasing | false | false |
| 21 | 18 | The Princess and the Frog | $772 | -59.9% | 1 | -1 | $772 | $80,818 | 8 | Walt Disney Pictures | false | false |
| 22 | 17 | Paris 36 | $649 | -68% | 2 | - | $324 | $8,388 | 3 | N/A | false | false |
| 23 | 20 | Paranormal Activity | $429 | -51.9% | 1 | - | $429 | $58,797 | 9 | N/A | false | false |
| 24 | 19 | Astro Boy | $208 | -79.8% | 3 | -1 | $69 | $30,493 | 5 | N/A | false | false |
