| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $74,867 | -43.3% | 8 | - | $9,358 | $1,988,003 | 11 | 20th Century Fox International | false | false |
| 2 | - | The Wolfman | $50,648 | - | 9 | - | $5,627 | $50,648 | 1 | United International Pictures | true | false |
| 3 | 3 | My Name Is Khan | $34,552 | -18.4% | 8 | - | $4,319 | $83,968 | 2 | 20th Century Fox International | false | false |
| 4 | 2 | Valentine's Day | $29,216 | -40% | 5 | - | $5,843 | $172,539 | 3 | Warner Bros. | false | false |
| 5 | 4 | The Book of Eli | $21,666 | -33.1% | 8 | - | $2,708 | $218,423 | 5 | - | false | false |
| 6 | 5 | Percy Jackson & the Olympians: The Lightning Thief | $11,803 | -44.2% | 8 | - | $1,475 | $72,433 | 3 | 20th Century Fox International | false | false |
| 7 | - | Stag Night | $10,985 | - | 3 | - | $3,661 | $10,985 | 1 | N/A | true | false |
| 8 | 8 | It's Complicated | $10,585 | -33.9% | 6 | - | $1,764 | $89,600 | 4 | United International Pictures | false | false |
| 9 | 7 | Sherlock Holmes | $9,676 | -41% | 5 | - | $1,935 | $379,691 | 9 | Warner Bros. | false | false |
| 10 | 6 | Up in the Air | $8,575 | -52.8% | 5 | - | $1,715 | $52,856 | 3 | United International Pictures | false | false |
| 11 | 10 | Old Dogs | $5,542 | -44.1% | 4 | +1 | $1,385 | $116,741 | 8 | Walt Disney Pictures | false | false |
| 12 | 9 | Alvin and the Chipmunks: The Squeakquel | $4,925 | -52.7% | 3 | -1 | $1,641 | $144,049 | 10 | 20th Century Fox International | false | false |
| 13 | 11 | Triangle | $3,998 | -55% | 3 | -1 | $1,332 | $59,137 | 4 | N/A | false | false |
| 14 | 12 | The Princess and the Frog | $3,396 | -23.7% | 2 | - | $1,698 | $73,342 | 9 | Walt Disney Pictures | false | false |
| 15 | 13 | Did You Hear About the Morgans? | $3,062 | -26.3% | 2 | -1 | $1,531 | $59,541 | 5 | Sony Pictures Releasing | false | false |
| 16 | 15 | Nine | $1,206 | -36.9% | 3 | -1 | $402 | $73,459 | 6 | N/A | false | false |
| 17 | 17 | 2012 | $752 | -16.3% | 3 | -1 | $250 | $1,099,055 | 16 | Sony Pictures Releasing | false | false |
| 18 | 14 | High Lane | $703 | -77.2% | 3 | -1 | $234 | $21,147 | 5 | N/A | false | false |
| 19 | 18 | The Ugly Duckling and Me! | $289 | -45.6% | 1 | -1 | $289 | $5,296 | 4 | N/A | false | false |
| 20 | 20 | The Box | $275 | -11% | 1 | - | $275 | $30,534 | 7 | N/A | false | false |
| 21 | 19 | Franklyn | $147 | -69.9% | 1 | -1 | $147 | $7,773 | 5 | N/A | false | false |
| 22 | 16 | Cirque du Freak: The Vampire's Assistant | $144 | -89.7% | 2 | - | $72 | $41,887 | 12 | United International Pictures | false | false |
