| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Valentine's Day | $52,410,000 | $56,260,707 | +$3,850,707 | +7.3% | 3,665 | $52,410,000 | $56,260,707 | 1 | Warner Bros. | - |
| 2 | 3 | +1 | Percy Jackson & the Olympians: The Lightning Thief | $31,100,000 | $31,236,067 | +$136,067 | +0.4% | 3,356 | $31,150,000 | $31,236,067 | 1 | Twentieth Century Fox | - |
| 3 | 2 | -1 | The Wolfman | $30,627,000 | $31,479,235 | +$852,235 | +2.8% | 3,222 | $30,627,000 | $31,479,235 | 1 | Universal Pictures | - |
| 4 | 4 | - | Avatar | $22,000,000 | $23,611,625 | +$1,611,625 | +7.3% | 2,685 | $659,605,000 | $661,217,278 | 9 | Twentieth Century Fox | - |
| 5 | 5 | - | Dear John | $15,300,000 | $16,071,526 | +$771,526 | +5% | 2,975 | $53,178,000 | $53,949,098 | 2 | Screen Gems | - |
| 6 | 6 | - | Tooth Fairy | $5,600,000 | $6,054,257 | +$454,257 | +8.1% | 2,748 | $41,528,000 | $41,982,992 | 4 | Twentieth Century Fox | - |
| 7 | 7 | - | From Paris with Love | $4,740,000 | $5,495,113 | +$755,113 | +15.9% | 2,722 | $15,850,000 | $16,607,903 | 2 | Lionsgate | - |
| 8 | 8 | - | Edge of Darkness | $4,585,000 | $4,841,295 | +$256,295 | +5.6% | 2,615 | $36,069,000 | $36,324,976 | 3 | Warner Bros. | - |
| 9 | 9 | - | Crazy Heart | $4,000,000 | $4,265,989 | +$265,989 | +6.6% | 1,005 | $16,526,000 | $16,792,964 | 9 | - | - |
| 10 | 10 | - | When in Rome | $3,429,000 | $3,682,881 | +$253,881 | +7.4% | 2,125 | $26,027,000 | $26,280,610 | 3 | Walt Disney Studios Motion Pictures | - |
| 11 | 11 | - | The Book of Eli | $3,275,000 | $3,631,838 | +$356,838 | +10.9% | 1,825 | $87,229,000 | $87,586,069 | 5 | Warner Bros. | - |
| 12 | 12 | - | The Blind Side | $2,210,000 | $2,261,787 | +$51,787 | +2.3% | 1,175 | $244,676,000 | $244,728,128 | 13 | Warner Bros. | - |
| 13 | 13 | - | My Name Is Khan | $1,860,000 | $1,944,027 | +$84,027 | +4.5% | 120 | $1,860,000 | $1,944,027 | 1 | - | - |
| 14 | 15 | +1 | Up in the Air | $1,700,000 | $1,773,750 | +$73,750 | +4.3% | 925 | $79,138,000 | $79,212,519 | 11 | Paramount Pictures | - |
| 15 | 16 | +1 | Sherlock Holmes | $1,540,000 | $1,591,601 | +$51,601 | +3.4% | 950 | $204,004,000 | $204,055,200 | 8 | Warner Bros. | - |
| 16 | 14 | -2 | Legion | $1,525,000 | $1,830,167 | +$305,167 | +20% | 1,424 | $37,627,000 | $37,932,062 | 4 | Screen Gems | - |
| 17 | 18 | +1 | It's Complicated | $1,228,000 | $1,215,915 | -$12,085 | -1% | 787 | $109,746,000 | $109,560,840 | 8 | Universal Pictures | - |
| 18 | 17 | -1 | Alvin and the Chipmunks: The Squeakquel | $1,200,000 | $1,280,651 | +$80,651 | +6.7% | 1,057 | $213,815,000 | $213,896,122 | 8 | Twentieth Century Fox | - |
| 19 | 19 | - | The Lovely Bones | $600,000 | $690,285 | +$90,285 | +15% | 833 | $42,757,600 | $42,847,901 | 10 | DreamWorks | - |
| 20 | 20 | - | The Princess and the Frog | $571,000 | $607,920 | +$36,920 | +6.5% | 441 | $101,710,000 | $101,747,606 | 12 | Walt Disney Studios Motion Pictures | - |
| 21 | 21 | - | The Twilight Saga: New Moon | $559,000 | $558,713 | -$287 | <0.1% | 398 | $294,931,900 | $294,931,622 | 13 | Summit Entertainment | - |
| 22 | 22 | - | The Last Station | $528,000 | $514,597 | -$13,403 | -2.5% | 84 | $1,386,000 | $1,372,873 | 5 | Sony Pictures Classics | - |
| 23 | 24 | +1 | An Education | $486,000 | $471,838 | -$14,162 | -2.9% | 333 | $10,466,000 | $10,452,204 | 19 | Sony Pictures Classics | - |
| 24 | 23 | -1 | A Single Man | $473,000 | $476,156 | +$3,156 | +0.7% | 313 | $6,913,000 | $6,916,715 | 10 | The Weinstein Company | - |
| 25 | 25 | - | The Spy Next Door | $310,000 | $412,191 | +$102,191 | +33% | 403 | $23,400,000 | $23,501,520 | 5 | Lionsgate | - |
| 26 | 26 | - | The Young Victoria | $283,000 | $303,583 | +$20,583 | +7.3% | 215 | $8,807,000 | $9,426,964 | 9 | Apparition | - |
| 27 | 27 | - | Precious | $180,000 | $210,844 | +$30,844 | +17.1% | 269 | $46,490,000 | $46,520,765 | 15 | Lionsgate | - |
| 28 | 29 | +1 | The White Ribbon | $156,000 | $166,413 | +$10,413 | +6.7% | 45 | $1,001,000 | $1,011,186 | 7 | Sony Pictures Classics | - |
| 29 | 30 | +1 | The Imaginarium of Doctor Parnassus | $150,000 | $164,601 | +$14,601 | +9.7% | 102 | $7,013,000 | $7,027,802 | 8 | Sony Pictures Classics | - |
| 30 | 31 | +1 | Leap Year | $139,000 | $138,625 | -$375 | -0.3% | 235 | $25,644,000 | $25,621,995 | 6 | Universal Pictures | - |
| 31 | 36 | +5 | Broken Embraces | $83,000 | $85,820 | +$2,820 | +3.4% | 71 | $4,423,900 | $4,426,727 | 13 | Sony Pictures Classics | - |
| 32 | 40 | +8 | Nine | $39,200 | $43,374 | +$4,174 | +10.6% | 81 | $19,520,500 | $19,524,634 | 9 | The Weinstein Company | - |
| 33 | 43 | +10 | The Messenger | $34,500 | $38,024 | +$3,524 | +10.2% | 30 | $848,800 | $852,362 | 14 | Oscilloscope | - |
| 34 | 50 | +16 | Saint John of Las Vegas | $24,500 | $24,048 | -$452 | -1.8% | 14 | $68,400 | $67,955 | 3 | IndieVest Pictures | - |
| 35 | 51 | +16 | Terribly Happy | $22,100 | $21,911 | -$189 | -0.9% | 5 | $38,600 | $38,603 | 2 | Oscilloscope | - |
| 36 | 45 | +9 | Preacher's Kid | $21,400 | $29,592 | +$8,192 | +38.3% | 27 | $347,500 | $355,676 | 3 | 8x Entertainment | - |
| 37 | 46 | +9 | Youth in Revolt | $21,100 | $26,622 | +$5,522 | +26.2% | 35 | $15,139,300 | $15,144,770 | 6 | - | - |
| 38 | 53 | +15 | The Road | $17,100 | $19,026 | +$1,926 | +11.3% | 40 | $7,955,400 | $7,957,335 | 12 | - | - |
| 39 | 48 | +9 | Creation | $15,900 | $25,368 | +$9,468 | +59.5% | 8 | $164,700 | $174,111 | 4 | Newmarket Films | - |
| 40 | 59 | +19 | Red Riding: The Year of Our Lord 1974 | $13,000 | $13,374 | +$374 | +2.9% | 2 | $37,200 | $37,666 | 2 | IFC Films | - |
| 41 | 60 | +19 | Bad Lieutenant: Port of Call New Orleans | $11,300 | $12,058 | +$758 | +6.7% | 16 | $1,673,451 | $1,674,209 | 13 | First Look International | - |
