| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $131,962 | -25.8% | 8 | - | $16,495 | $1,893,694 | 10 | 20th Century Fox International | false | false |
| 2 | 2 | Valentine's Day | $48,656 | -28.2% | 5 | - | $9,731 | $134,481 | 2 | Warner Bros. | false | false |
| 3 | - | My Name Is Khan | $42,362 | - | 8 | - | $5,295 | $42,362 | 1 | 20th Century Fox International | true | false |
| 4 | 3 | The Book of Eli | $32,362 | -20.3% | 8 | - | $4,045 | $191,346 | 4 | - | false | false |
| 5 | 4 | Percy Jackson & the Olympians: The Lightning Thief | $21,170 | -24.2% | 8 | - | $2,646 | $57,212 | 2 | 20th Century Fox International | false | false |
| 6 | 7 | Up in the Air | $18,163 | -8.9% | 5 | - | $3,632 | $41,820 | 2 | United International Pictures | false | false |
| 7 | 5 | Sherlock Holmes | $16,405 | -28.6% | 5 | -2 | $3,281 | $367,847 | 8 | Warner Bros. | false | false |
| 8 | 6 | It's Complicated | $16,025 | -25.5% | 6 | - | $2,670 | $76,908 | 3 | United International Pictures | false | false |
| 9 | 8 | Alvin and the Chipmunks: The Squeakquel | $10,402 | -27.8% | 4 | - | $2,600 | $138,225 | 9 | 20th Century Fox International | false | false |
| 10 | 10 | Old Dogs | $9,914 | -7% | 3 | -1 | $3,304 | $110,077 | 7 | Walt Disney Pictures | false | false |
| 11 | 9 | Triangle | $8,881 | -22.3% | 4 | -1 | $2,220 | $53,556 | 3 | N/A | false | false |
| 12 | 13 | The Princess and the Frog | $4,451 | -20.2% | 2 | - | $2,225 | $69,233 | 8 | Walt Disney Pictures | false | false |
| 13 | 11 | Did You Hear About the Morgans? | $4,152 | -46.5% | 3 | -1 | $1,384 | $55,683 | 4 | Sony Pictures Releasing | false | false |
| 14 | 14 | High Lane | $3,080 | +28.3% | 4 | -1 | $770 | $19,728 | 4 | N/A | false | false |
| 15 | 12 | Nine | $1,912 | -67.4% | 4 | - | $478 | $71,951 | 5 | N/A | false | false |
| 16 | 17 | Cirque du Freak: The Vampire's Assistant | $1,402 | -33.7% | 2 | - | $701 | $41,615 | 11 | United International Pictures | false | false |
| 17 | 15 | 2012 | $898 | -60.5% | 4 | - | $224 | $1,098,016 | 15 | Sony Pictures Releasing | false | false |
| 18 | 18 | The Ugly Duckling and Me! | $531 | +92.4% | 2 | +1 | $265 | $4,891 | 3 | N/A | false | false |
| 19 | - | Franklyn | $489 | - | 2 | - | $244 | $7,626 | 4 | N/A | false | false |
| 20 | 16 | The Box | $309 | -85.8% | 1 | -2 | $309 | $30,235 | 6 | N/A | false | false |
| 21 | 19 | Couples Retreat | $237 | +48.1% | 1 | - | $237 | $98,269 | 13 | United International Pictures | false | false |
