| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Tooth Fairy | $145,477 | -14.8% | 31 | - | $4,692 | $398,290 | 2 | 20th Century Fox International | false | false |
| 2 | 2 | Avatar | $84,587 | +5% | 35 | - | $2,416 | $2,411,627 | 8 | 20th Century Fox International | false | false |
| 3 | - | Toy Story 2 2009 Re-release | $80,685 | - | 14 | - | $5,763 | $80,685 | 1 | Walt Disney Pictures | true | false |
| 4 | - | Sherlock Holmes | $38,000 | - | 28 | - | $1,357 | $493,965 | 4 | - | false | false |
| 5 | 4 | Everybody's Fine | $14,844 | -33.2% | 12 | - | $1,237 | $50,938 | 2 | Walt Disney Pictures | false | false |
| 6 | 6 | Alvin and the Chipmunks: The Squeakquel | $9,897 | -45.4% | 23 | -2 | $430 | $775,029 | 7 | 20th Century Fox International | false | false |
| 7 | - | The Informant! | $9,005 | - | 7 | - | $1,286 | $9,005 | 1 | - | true | false |
| 8 | 5 | Up in the Air | $8,702 | -55.4% | 15 | - | $580 | $100,071 | 3 | United International Pictures | false | false |
| 9 | - | Coco Before Chanel | $8,181 | - | 9 | - | $909 | $37,439 | 8 | - | false | false |
| 10 | 7 | The Princess and the Frog | $7,035 | -42% | 17 | -12 | $413 | $755,068 | 7 | Walt Disney Pictures | false | false |
| 11 | 8 | Nine | $6,695 | -33.3% | 7 | - | $956 | $20,944 | 2 | Sony Pictures Releasing | false | false |
| 12 | - | A Boyfriend for My Wife | $5,030 | - | 7 | - | $718 | $39,493 | 14 | - | false | false |
| 13 | - | Whiteout | $1,763 | - | 4 | - | $440 | $111,343 | 14 | - | false | false |
| 14 | - | Astro Boy | $1,436 | - | 13 | - | $110 | $60,064 | 3 | N/A | false | false |
| 15 | - | Over Her Dead Body | $1,409 | - | 1 | - | $1,409 | $41,232 | 6 | - | false | false |
| 16 | - | The Hangover | $1,160 | - | 1 | - | $1,160 | $207,260 | 25 | - | false | false |
| 17 | 3 | Toy Story 2009 Re-release | $950 | -98.4% | 2 | -12 | $475 | $202,181 | 3 | Walt Disney Pictures | false | false |
| 18 | 9 | Zombieland | $922 | -72.9% | 4 | -2 | $230 | $98,845 | 5 | Sony Pictures Releasing | false | false |
| 19 | 10 | Inglourious Basterds | $838 | -47.9% | 3 | - | $279 | $1,224 | 6 | United International Pictures | false | false |
