| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Sherlock Holmes | $5,891,136 | - | 676 | - | $8,714 | $5,891,136 | 1 | Warner Bros. | true | false |
| 2 | 1 | Avatar | $5,832,368 | -26.1% | 659 | -21 | $8,850 | $136,424,847 | 8 | 20th Century Fox International | false | false |
| 3 | 2 | The Princess and the Frog | $5,307,423 | -30.4% | 674 | +7 | $7,874 | $13,240,485 | 2 | Walt Disney Pictures | false | false |
| 4 | 3 | Oceans | $4,080,911 | -31.1% | 551 | +9 | $7,406 | $11,094,903 | 2 | N/A | false | false |
| 5 | 4 | Invictus | $2,434,169 | -30.9% | 495 | -2 | $4,917 | $20,310,520 | 4 | Warner Bros. | false | false |
| 6 | - | Planet 51 | $1,625,264 | - | 454 | - | $3,579 | $1,625,264 | 1 | N/A | true | false |
| 7 | 5 | Up in the Air | $1,516,710 | -43.3% | 312 | - | $4,861 | $4,589,458 | 2 | Paramount Pictures International | false | false |
| 8 | 6 | Gainsbourg: A Heroic Life | $1,204,796 | -44.7% | 483 | -16 | $2,494 | $8,397,555 | 3 | Universal Pictures International (UPI) | false | false |
| 9 | - | Brothers | $1,093,563 | - | 186 | - | $5,879 | $1,093,563 | 1 | Wild Bunch Distribution | true | false |
| 10 | - | An Ordinary Execution | $678,891 | - | 157 | - | $4,324 | $678,891 | 1 | StudioCanal | true | false |
| 11 | 9 | A Serious Man | $580,000 | -29.1% | 157 | +2 | $3,694 | $3,040,774 | 3 | StudioCanal | false | false |
| 12 | 7 | The Book of Eli | $516,894 | -58.9% | 272 | -106 | $1,900 | $4,411,090 | 3 | Metropolitan Filmexport | false | false |
| 13 | 8 | Did You Hear About the Morgans? | $367,448 | -65.1% | 207 | -106 | $1,775 | $3,819,184 | 3 | Sony Pictures Releasing | false | false |
| 14 | 10 | A Spot of Bother | $187,242 | -67.2% | 198 | -115 | $945 | $4,539,618 | 4 | UGC Distribution | false | false |
| 15 | 11 | Alvin and the Chipmunks: The Squeakquel | $184,426 | -61.4% | 178 | -105 | $1,036 | $12,184,528 | 7 | 20th Century Fox International | false | false |
| 16 | - | Lebanon | $172,084 | - | 39 | - | $4,412 | $172,084 | 1 | CTV International | true | false |
| 17 | - | Protéger & servir | $164,152 | - | 345 | - | $475 | $164,152 | 1 | N/A | true | false |
| 18 | - | Disgrace | $103,943 | - | 68 | - | $1,528 | $103,943 | 1 | Bac Films | true | false |
| 19 | - | Yona Yona Penguin | $27,790 | - | 56 | - | $496 | $27,790 | 1 | Gébéka Films | true | false |
| 20 | - | Anvil | $26,105 | - | 13 | - | $2,008 | $26,105 | 1 | N/A | true | false |
| 21 | 17 | Armored | $13,166 | -79.5% | 6 | -26 | $2,194 | $960,461 | 4 | Sony Pictures Releasing | false | false |
