| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Avatar | $1,663,426 | -24% | 447 | -25 | $3,721 | $34,726,955 | 6 | 20th Century Fox International | false | false |
| 2 | 2 | Tooth Fairy | $1,296,164 | -30.7% | 399 | -101 | $3,248 | $3,863,332 | 2 | 20th Century Fox International | false | false |
| 3 | 3 | Sherlock Holmes | $614,084 | -43.6% | 433 | -27 | $1,418 | $10,105,497 | 4 | Warner Bros. | false | false |
| 4 | - | Up in the Air | $589,517 | - | 251 | - | $2,348 | $589,517 | 1 | Paramount Pictures International | true | false |
| 5 | - | The Fourth Kind | $490,072 | - | 225 | - | $2,178 | $490,072 | 1 | Gussi Films | true | false |
| 6 | - | Invictus | $436,993 | - | 201 | - | $2,174 | $436,993 | 1 | Warner Bros. | true | false |
| 7 | 4 | Alvin and the Chipmunks: The Squeakquel | $274,983 | -48.2% | 363 | -72 | $757 | $9,620,951 | 5 | 20th Century Fox International | false | false |
| 8 | 5 | Did You Hear About the Morgans? | $235,624 | -48.8% | 206 | -10 | $1,143 | $928,736 | 2 | Sony Pictures Releasing | false | false |
| 9 | 6 | Paranormal Activity | $228,204 | -37.2% | 248 | -37 | $920 | $5,364,313 | 5 | Gussi Films | false | false |
| 10 | 8 | Zombieland | $129,507 | -15.8% | 161 | -20 | $804 | $807,610 | 3 | Sony Pictures Releasing | false | false |
| 11 | 7 | Law Abiding Citizen | $117,229 | -62.9% | 137 | -106 | $855 | $1,376,190 | 3 | N/A | false | false |
| 12 | 25 | All About Steve | $89,721 | +1,174.8% | 85 | +68 | $1,055 | $656,039 | 4 | 20th Century Fox International | false | false |
| 13 | 9 | Case 39 | $74,398 | -44.4% | 103 | -23 | $722 | $3,223,613 | 8 | Paramount Pictures International | false | false |
| 14 | 13 | Everybody's Fine | $72,121 | -31.6% | 100 | -6 | $721 | $1,224,900 | 5 | Walt Disney Pictures | false | false |
| 15 | 12 | The Princess and the Frog | $43,823 | -58.4% | 99 | -71 | $442 | $6,015,099 | 7 | Walt Disney Pictures | false | false |
| 16 | 17 | The Stepfather | $41,105 | -23.2% | 79 | -3 | $520 | $505,317 | 7 | Sony Pictures Releasing | false | false |
| 17 | 10 | Fame | $33,410 | -73.1% | 65 | -86 | $514 | $213,109 | 2 | N/A | false | false |
| 18 | 18 | Old Dogs | $22,458 | -57.6% | 30 | -40 | $748 | $5,066,976 | 9 | Walt Disney Pictures | false | false |
| 19 | 11 | Ninja Assassin | $21,805 | -80.2% | 73 | -47 | $298 | $205,336 | 2 | Warner Bros. | false | false |
| 20 | 16 | The Box | $21,002 | -73.8% | 57 | -50 | $368 | $1,277,554 | 7 | Videocine | false | false |
| 21 | 19 | Mutant Chronicles | $20,826 | -37.7% | 39 | -57 | $534 | $237,338 | 3 | Videocine | false | false |
| 22 | 14 | Pandorum | $16,119 | -80.9% | 66 | -34 | $244 | $155,595 | 2 | Gussi Films | false | false |
| 23 | 15 | Labor Pains | $13,260 | -83.9% | 41 | -121 | $323 | $499,585 | 3 | N/A | false | false |
| 24 | 20 | New York, I Love You | $9,550 | -59.8% | 15 | -14 | $636 | $325,596 | 6 | N/A | false | false |
| 25 | 21 | Julie & Julia | $8,447 | -57.3% | 14 | -11 | $603 | $537,518 | 14 | Sony Pictures Releasing | false | false |
| 26 | 22 | Nikté | $6,177 | -52.9% | 23 | -12 | $268 | $1,292,380 | 6 | Universal Pictures International (UPI) | false | false |
| 27 | 23 | The Milk of Sorrow | $6,175 | -51% | 8 | -2 | $771 | $29,309 | 2 | N/A | false | false |
| 28 | 26 | Opium: Diary of a Madwoman | $4,193 | -31.6% | 3 | -6 | $1,397 | $36,798 | 3 | N/A | false | false |
| 29 | 29 | Paris | $2,333 | -14.1% | 5 | -2 | $466 | $68,958 | 7 | N/A | false | false |
| 30 | 28 | Lemon Tree | $2,045 | -36.2% | 3 | - | $681 | $49,236 | 5 | N/A | false | false |
| 31 | 31 | Easy Virtue | $1,155 | -19.7% | 6 | +2 | $192 | $66,883 | 8 | Sony Pictures Releasing | false | false |
| 32 | 27 | 2012 | $1,144 | -80% | 10 | -12 | $114 | $19,423,148 | 11 | Sony Pictures Releasing | false | false |
