| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | This Is It | $105,177 | -59.3% | 81 | - | $1,298 | $1,095,330 | 3 | N/A | false | false |
| 2 | 2 | Law Abiding Citizen | $96,187 | -28.8% | 51 | - | $1,886 | $311,398 | 2 | N/A | false | false |
| 3 | 3 | A Christmas Carol | $91,294 | -13% | 81 | +5 | $1,127 | $229,519 | 2 | N/A | false | false |
| 4 | - | Surrogates | $81,457 | - | 45 | - | $1,810 | $81,457 | 1 | N/A | true | false |
| 5 | - | Julie & Julia | $70,317 | - | 15 | - | $4,687 | $70,317 | 1 | N/A | true | false |
| 6 | 4 | The Ugly Truth | $66,870 | -18.2% | 54 | - | $1,238 | $1,096,313 | 6 | N/A | false | false |
| 7 | 6 | Cloudy with a Chance of Meatballs | $51,606 | -16.7% | 56 | - | $921 | $528,055 | 5 | N/A | false | false |
| 8 | 5 | Inglourious Basterds | $49,324 | -25.1% | 56 | -3 | $880 | $510,968 | 4 | N/A | false | false |
| 9 | 9 | Jennifer's Body | $16,426 | -14.8% | 23 | - | $714 | $194,433 | 5 | N/A | false | false |
| 10 | 8 | Up | $15,473 | -30.6% | 21 | -11 | $736 | $1,987,106 | 10 | Ster-Kinekor Pictures | false | false |
| 11 | 7 | Gamer | $15,043 | -35.5% | 25 | -6 | $601 | $191,950 | 4 | N/A | false | false |
| 12 | 12 | Imagine That | $14,792 | -1.7% | 26 | -2 | $568 | $507,253 | 8 | N/A | false | false |
| 13 | 11 | The Final Destination | $12,139 | -24.9% | 21 | - | $578 | $573,338 | 7 | N/A | false | false |
| 14 | 10 | The Taking of Pelham 123 | $9,023 | -46.4% | 23 | -6 | $392 | $864,359 | 8 | N/A | false | false |
| 15 | 15 | Aliens in the Attic | $8,886 | -9.5% | 17 | +1 | $522 | $184,291 | 7 | N/A | false | false |
| 16 | 13 | Whatever Works | $6,499 | -41.8% | 11 | - | $590 | $43,895 | 3 | N/A | false | false |
| 17 | 17 | Fireflies in the Garden | $5,052 | -34.6% | 10 | - | $505 | $17,330 | 2 | N/A | false | false |
| 18 | - | The Time Traveler's Wife | $3,446 | - | 7 | - | $492 | $417,300 | 10 | NuMetro Distribution | false | false |
| 19 | 20 | Dance Flick | $907 | -22.4% | 5 | - | $181 | $79,526 | 10 | United International Pictures | false | false |
| 20 | 21 | Public Enemies | $236 | +18% | 2 | - | $118 | $471,361 | 11 | United International Pictures | false | false |
| 21 | 22 | Looking for Eric | $86 | -56.8% | 1 | -1 | $86 | $25,523 | 6 | N/A | false | false |
