| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | The Ugly Truth | $141,992 | -50.4% | 53 | -1 | $2,679 | $526,618 | 2 | N/A | false | false |
| 2 | - | Cloudy with a Chance of Meatballs | $122,731 | - | 69 | - | $1,778 | $122,731 | 1 | N/A | true | false |
| 3 | 2 | Up | $70,006 | -37.2% | 59 | -9 | $1,186 | $1,791,217 | 6 | Ster-Kinekor Pictures | false | false |
| 4 | 4 | The Taking of Pelham 123 | $56,863 | -25.8% | 63 | -3 | $902 | $687,960 | 4 | N/A | false | false |
| 5 | 3 | The Final Destination | $49,794 | -48.8% | 33 | - | $1,508 | $399,112 | 3 | N/A | false | false |
| 6 | - | Jennifer's Body | $42,364 | - | 25 | - | $1,694 | $42,364 | 1 | N/A | true | false |
| 7 | 5 | Fame | $33,367 | -27.2% | 61 | - | $547 | $558,285 | 4 | N/A | false | false |
| 8 | 6 | Imagine That | $26,325 | -33.6% | 42 | - | $626 | $398,482 | 4 | N/A | false | false |
| 9 | - | The Informant! | $23,157 | - | 15 | - | $1,543 | $23,157 | 1 | N/A | true | false |
| 10 | 7 | Last Chance Harvey | $21,086 | -38.6% | 13 | -2 | $1,622 | $137,258 | 3 | N/A | false | false |
| 11 | 9 | Aliens in the Attic | $21,002 | -34.8% | 20 | - | $1,050 | $120,155 | 3 | N/A | false | false |
| 12 | 8 | Blood: The Last Vampire | $19,636 | -40.8% | 25 | - | $785 | $68,340 | 2 | N/A | false | false |
| 13 | - | Me and Mrs. Khanna | $16,611 | - | 7 | - | $2,373 | $16,611 | 1 | N/A | true | false |
| 14 | 10 | District 9 | $12,269 | -48.1% | 22 | -10 | $557 | $1,299,600 | 8 | Ster-Kinekor Pictures | false | false |
| 15 | 13 | The Proposal | $10,894 | -26.1% | 16 | -6 | $680 | $2,759,912 | 15 | Ster-Kinekor Pictures | false | false |
| 16 | 11 | The Time Traveler's Wife | $8,397 | -47.1% | 26 | -3 | $322 | $385,001 | 6 | NuMetro Distribution | false | false |
| 17 | 16 | Looking for Eric | $5,821 | -41.8% | 21 | - | $277 | $20,301 | 2 | N/A | false | false |
| 18 | 14 | G.I. Joe: The Rise of Cobra | $5,065 | -53.9% | 12 | -16 | $422 | $1,335,483 | 10 | United International Pictures | false | false |
| 19 | 19 | Public Enemies | $4,411 | -21.5% | 12 | -4 | $367 | $419,501 | 7 | United International Pictures | false | false |
| 20 | 20 | Dance Flick | $1,435 | -56% | 6 | -2 | $239 | $69,805 | 6 | United International Pictures | false | false |
| 21 | 22 | Adoration | $108 | -21.2% | 1 | -1 | $108 | $11,620 | 5 | United International Pictures | false | false |
| 22 | 21 | Disgrace | $90 | -92.5% | 1 | -2 | $90 | $72,366 | 10 | United International Pictures | false | false |
