| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Cloudy with a Chance of Meatballs | $1,326,762 | - | 250 | - | $5,307 | $1,326,762 | 1 | Sony Pictures Releasing | true | false |
| 2 | 2 | The Ugly Truth | $795,210 | -0.6% | 164 | - | $4,848 | $3,613,884 | 3 | Sony Pictures Releasing | false | false |
| 3 | 1 | Up | $472,650 | -46.9% | 250 | -68 | $1,890 | $9,141,998 | 5 | Walt Disney Pictures | false | false |
| 4 | 4 | The Hangover | $458,091 | +4.2% | 182 | -2 | $2,516 | $6,513,216 | 7 | Warner Bros. | false | false |
| 5 | 3 | So Normal 2: The Craziest Night Ever | $435,423 | -16.4% | 354 | -25 | $1,230 | $9,401,193 | 6 | N/A | false | false |
| 6 | - | Time of Fear | $415,424 | - | 186 | - | $2,233 | $415,560 | 1 | Sony Pictures Releasing | true | false |
| 7 | - | Gamer | $254,362 | - | 102 | - | $2,493 | $254,362 | 1 | N/A | true | false |
| 8 | 5 | The Taking of Pelham 123 | $225,689 | -29.6% | 174 | -7 | $1,297 | $3,726,400 | 5 | Sony Pictures Releasing | false | false |
| 9 | - | Whiteout | $119,966 | - | 49 | - | $2,448 | $119,966 | 1 | Warner Bros. | true | false |
| 10 | 7 | Spread | $98,054 | -30.5% | 48 | -4 | $2,042 | $311,552 | 2 | N/A | false | false |
| 11 | 6 | Aliens in the Attic | $83,415 | -53.2% | 84 | +1 | $993 | $329,291 | 2 | 20th Century Fox International | false | false |
| 12 | 8 | My Sister's Keeper | $83,399 | -33.5% | 90 | -4 | $926 | $999,996 | 4 | PlayArte Pictures | false | false |
| 13 | 9 | Sorority Row | $56,518 | -54% | 74 | -6 | $763 | $250,641 | 2 | Paris Filmes | false | false |
| 14 | 11 | Orphan | $46,378 | -16.3% | 60 | -15 | $772 | $729,223 | 5 | Warner Bros. | false | false |
| 15 | 13 | Two Lovers | $35,290 | -12% | 32 | -12 | $1,102 | $606,881 | 6 | PlayArte Pictures | false | false |
| 16 | 12 | G-Force | $32,099 | -26.1% | 160 | -13 | $200 | $4,253,811 | 8 | Walt Disney Pictures | false | false |
| 17 | 10 | My Life in Ruins | $28,415 | -59.9% | 69 | -43 | $411 | $778,069 | 4 | N/A | false | false |
| 18 | 17 | The Proposal | $8,516 | -33.6% | 14 | -22 | $608 | $7,328,628 | 13 | Walt Disney Pictures | false | false |
| 19 | 14 | Diary of a Nymphomaniac | $6,492 | -71.9% | 10 | -24 | $649 | $47,714 | 2 | PlayArte Pictures | false | false |
| 20 | 27 | Drag Me to Hell | $6,479 | +3.2% | 28 | -19 | $231 | $1,784,538 | 8 | Universal Pictures International (UPI) | false | false |
| 21 | 15 | Brüno | $5,861 | -59.9% | 14 | -20 | $418 | $1,164,219 | 8 | Sony Pictures Releasing | false | false |
| 22 | 31 | Ice Age: Dawn of the Dinosaurs | $4,759 | +4.7% | 75 | +33 | $63 | $45,337,850 | 14 | 20th Century Fox International | false | false |
| 23 | 19 | Shorts | $3,962 | -64.3% | 30 | -13 | $132 | $250,508 | 6 | Warner Bros. | false | false |
| 24 | 29 | Adrift | $3,752 | -24.9% | 19 | -4 | $197 | $467,939 | 10 | Universal Pictures International (UPI) | false | false |
| 25 | 20 | Bandslam | $3,527 | -67% | 32 | -33 | $110 | $137,712 | 4 | Paris Filmes | false | false |
| 26 | 18 | The Story of Me | $2,666 | -77.5% | 21 | -16 | $126 | $592,924 | 9 | Warner Bros. | false | false |
| 27 | 26 | Harry Potter and the Half-Blood Prince | $2,426 | -62.5% | 7 | -3 | $346 | $20,240,271 | 12 | Warner Bros. | false | false |
| 28 | 32 | The Invisible Woman | $2,411 | -30.1% | 10 | -9 | $241 | $11,433,290 | 18 | Warner Bros. | false | false |
| 29 | 25 | Time of Peace | $2,400 | -65.4% | 21 | -12 | $114 | $425,080 | 8 | N/A | false | false |
| 30 | 22 | G.I. Joe: The Rise of Cobra | $2,295 | -75.5% | 17 | -18 | $135 | $3,517,203 | 9 | Paramount Pictures International | false | false |
| 31 | 21 | Che: Part Two | $2,242 | -78.1% | 6 | -25 | $373 | $64,910 | 3 | Europa Filmes | false | false |
| 32 | 34 | The International | $441 | +16.7% | 5 | - | $88 | $625,421 | 16 | Sony Pictures Releasing | false | false |
| 33 | 36 | Hannah Montana: The Movie | $70 | +125.8% | 1 | - | $70 | $2,796,536 | 17 | Walt Disney Pictures | false | false |
