| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Taking of Pelham 123 | $83,565 | - | 33 | - | $2,532 | $83,565 | 1 | Sony Pictures Releasing | true | false |
| 2 | - | Dawson Isla 10 | $79,366 | - | 21 | - | $3,779 | $79,366 | 1 | N/A | true | false |
| 3 | 1 | Orphan | $69,497 | -25.1% | 23 | -1 | $3,021 | $326,317 | 3 | Warner Bros. | false | false |
| 4 | 3 | The Ugly Truth | $49,375 | -20.1% | 25 | - | $1,975 | $129,920 | 2 | Sony Pictures Releasing | false | false |
| 5 | 4 | The Hangover | $41,703 | -27.7% | 29 | - | $1,438 | $346,847 | 4 | Warner Bros. | false | false |
| 6 | 2 | Tinker Bell and the Lost Treasure | $40,941 | -36.5% | 33 | - | $1,240 | $115,210 | 2 | Walt Disney Pictures | false | false |
| 7 | 5 | Aliens in the Attic | $37,041 | -26.9% | 32 | - | $1,157 | $181,190 | 3 | 20th Century Fox International | false | false |
| 8 | 6 | G-Force | $30,661 | -35.7% | 42 | +2 | $730 | $1,406,210 | 8 | Walt Disney Pictures | false | false |
| 9 | 7 | The Maid | $20,764 | -26.3% | 20 | - | $1,038 | $347,212 | 5 | Andes Films | false | false |
| 10 | 8 | Last Chance Harvey | $17,405 | -20.7% | 12 | +2 | $1,450 | $88,142 | 3 | N/A | false | false |
| 11 | 9 | Ice Age: Dawn of the Dinosaurs | $12,865 | -32.7% | 24 | -8 | $536 | $6,869,813 | 11 | 20th Century Fox International | false | false |
| 12 | - | The Time Traveler's Wife | $11,899 | - | 6 | - | $1,983 | $11,899 | 1 | Warner Bros. | true | false |
| 13 | - | New in Town | $9,918 | - | 8 | - | $1,239 | $9,918 | 1 | N/A | true | false |
| 14 | 10 | Boogeyman 2 | $8,823 | -48.7% | 15 | +1 | $588 | $31,489 | 2 | N/A | false | false |
| 15 | 12 | The Proposal | $7,051 | -45.7% | 10 | -9 | $705 | $280,701 | 6 | Walt Disney Pictures | false | false |
| 16 | 11 | Public Enemies | $6,767 | -53.1% | 9 | -10 | $751 | $489,543 | 7 | United International Pictures | false | false |
| 17 | 13 | Shorts | $6,163 | -46.8% | 12 | -6 | $513 | $220,736 | 6 | Warner Bros. | false | false |
| 18 | 18 | My Bloody Valentine | $5,065 | -27% | 9 | +4 | $562 | $98,847 | 4 | N/A | false | false |
| 19 | 14 | Che: Part Two | $3,848 | -56.1% | 6 | -1 | $641 | $14,995 | 2 | N/A | false | false |
| 20 | - | The Edge of Heaven | $3,715 | - | 3 | - | $1,238 | $3,715 | 1 | Transeuropa | true | false |
| 21 | 17 | The Visitor | $2,860 | -61.5% | 3 | -1 | $953 | $12,448 | 2 | N/A | false | false |
| 22 | 15 | Harry Potter and the Half-Blood Prince | $2,341 | -70.2% | 7 | -8 | $334 | $3,484,234 | 9 | Warner Bros. | false | false |
| 23 | 19 | Bangkok Dangerous | $2,159 | -62.8% | 12 | -1 | $179 | $83,121 | 5 | N/A | false | false |
| 24 | 21 | State of Play | $2,038 | -38.4% | 5 | -6 | $407 | $80,637 | 5 | United International Pictures | false | false |
| 25 | 16 | G.I. Joe: The Rise of Cobra | $1,414 | -81.8% | 6 | -13 | $235 | $417,673 | 6 | United International Pictures | false | false |
| 26 | 20 | Transporter 3 | $1,361 | -73.7% | 4 | -6 | $340 | $29,432 | 3 | N/A | false | false |
| 27 | 22 | Up | $278 | -88.4% | 1 | -4 | $278 | $3,643,645 | 14 | Walt Disney Pictures | false | false |
