| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | G.I. Joe: The Rise of Cobra | $149,345 | -52.9% | 74 | - | $2,018 | $575,868 | 2 | United International Pictures | false | false |
| 2 | 3 | G-Force | $110,556 | +1.1% | 64 | -1 | $1,727 | $786,887 | 4 | Ster-Kinekor Pictures | false | false |
| 3 | 2 | My Sister's Keeper | $87,906 | -49.6% | 45 | - | $1,953 | $329,801 | 2 | NuMetro Distribution | false | false |
| 4 | 4 | The Proposal | $83,578 | -9.9% | 64 | -1 | $1,305 | $2,063,905 | 7 | Ster-Kinekor Pictures | false | false |
| 5 | - | Year One | $41,712 | - | 20 | - | $2,085 | $41,712 | 1 | Ster-Kinekor Pictures | true | false |
| 6 | 5 | The Hangover | $38,755 | -21% | 52 | -3 | $745 | $1,787,678 | 10 | NuMetro Distribution | false | false |
| 7 | 7 | Ice Age: Dawn of the Dinosaurs | $31,343 | -28.5% | 53 | -14 | $591 | $3,253,719 | 8 | NuMetro Distribution | false | false |
| 8 | 8 | Fired Up! | $28,424 | -29.9% | 35 | -2 | $812 | $190,333 | 3 | Ster-Kinekor Pictures | false | false |
| 9 | 6 | Harry Potter and the Half-Blood Prince | $27,756 | -41.5% | 53 | -18 | $523 | $1,671,954 | 6 | NuMetro Distribution | false | false |
| 10 | - | Orphan | $26,503 | - | 25 | - | $1,060 | $26,503 | 1 | NuMetro Distribution | true | false |
| 11 | - | Not Easily Broken | $23,842 | - | 20 | - | $1,192 | $23,842 | 1 | NuMetro Distribution | true | false |
| 12 | 9 | My Life in Ruins | $23,262 | -27.8% | 33 | -2 | $704 | $278,881 | 4 | Ster-Kinekor Pictures | false | false |
| 13 | - | Izulu lami | $11,134 | - | 23 | - | $484 | $11,134 | 1 | Ster-Kinekor Pictures | true | false |
| 14 | 11 | Disgrace | $9,793 | -23.7% | 10 | - | $979 | $30,550 | 2 | United International Pictures | false | false |
| 15 | 10 | Fighting | $6,737 | -49.8% | 22 | -5 | $306 | $217,172 | 5 | United International Pictures | false | false |
| 16 | 17 | A Summer in Genoa | $6,284 | -18% | 8 | -2 | $785 | $41,443 | 3 | United International Pictures | false | false |
| 17 | 19 | Management | $4,987 | -11.8% | 9 | - | $554 | $71,398 | 5 | NuMetro Distribution | false | false |
| 18 | 15 | Virgin Territory | $4,782 | -51.7% | 9 | -1 | $531 | $44,692 | 3 | NuMetro Distribution | false | false |
| 19 | 16 | Knowing | $4,617 | -49.6% | 10 | -9 | $461 | $821,288 | 8 | United International Pictures | false | false |
| 20 | 12 | Transformers: Revenge of the Fallen | $4,531 | -60.6% | 9 | -11 | $503 | $2,391,690 | 9 | United International Pictures | false | false |
| 21 | 18 | Crossing Over | $4,384 | -24% | 8 | -1 | $548 | $77,151 | 6 | Ster-Kinekor Pictures | false | false |
| 22 | 21 | Obsessed | $3,180 | -36% | 8 | -3 | $397 | $323,395 | 10 | Ster-Kinekor Pictures | false | false |
| 23 | 20 | Brüno | $1,658 | -70.6% | 6 | -11 | $276 | $406,504 | 7 | United International Pictures | false | false |
| 24 | - | Sunshine Cleaning | $551 | - | 2 | - | $275 | $95,721 | 11 | United International Pictures | false | false |
