| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Inglourious Basterds | $22,931 | - | 6 | - | $3,821 | $30,357 | 1 | United International Pictures | true | false |
| 2 | 1 | Ice Age: Dawn of the Dinosaurs | $9,572 | -8.8% | 9 | - | $1,063 | $332,746 | 8 | 20th Century Fox International | false | false |
| 3 | 3 | The Proposal | $5,984 | -1.5% | 6 | - | $997 | $80,152 | 5 | Walt Disney Pictures | false | false |
| 4 | 2 | Harry Potter and the Half-Blood Prince | $4,143 | -34.8% | 8 | - | $517 | $170,226 | 6 | Warner Bros. | false | false |
| 5 | 4 | Public Enemies | $2,345 | -24.4% | 5 | - | $469 | $63,983 | 8 | United International Pictures | false | false |
| 6 | 5 | The Hangover | $2,028 | -19.7% | 5 | - | $405 | $134,115 | 10 | Warner Bros. | false | false |
| 7 | 6 | Knowing | $1,411 | -42.3% | 4 | - | $352 | $20,713 | 4 | N/A | false | false |
| 8 | 7 | Brüno | $1,321 | -42.1% | 6 | - | $220 | $61,224 | 7 | N/A | false | false |
| 9 | 14 | State of Play | $824 | +362.9% | 4 | - | $206 | $28,056 | 11 | United International Pictures | false | false |
| 10 | 9 | Transformers: Revenge of the Fallen | $419 | -44.8% | 8 | - | $52 | $81,940 | 9 | United International Pictures | false | false |
| 11 | 13 | Ghosts of Girlfriends Past | $389 | +79.3% | 5 | - | $77 | $56,359 | 11 | Warner Bros. | false | false |
| 12 | 12 | Hannah Montana: The Movie | $345 | +13.1% | 5 | - | $69 | $31,603 | 11 | Walt Disney Pictures | false | false |
| 13 | 10 | Coraline | $270 | -51.8% | 4 | - | $67 | $32,574 | 12 | United International Pictures | false | false |
| 14 | 18 | Slumdog Millionaire | $263 | +286.8% | 5 | - | $52 | $65,006 | 19 | N/A | false | false |
| 15 | 11 | Terminator Salvation | $232 | -44.1% | 4 | - | $58 | $90,914 | 12 | Sony Pictures Releasing | false | false |
| 16 | 8 | Angels & Demons | $215 | -74.2% | 2 | -4 | $107 | $163,623 | 15 | Sony Pictures Releasing | false | false |
| 17 | 15 | Night at the Museum: Battle of the Smithsonian | $209 | +64.6% | 6 | - | $34 | $60,931 | 14 | 20th Century Fox International | false | false |
| 18 | 20 | Taken | $28 | -33.3% | 2 | - | $14 | $4,970 | 10 | N/A | false | false |
| 19 | 21 | Hotel for Dogs | $9 | -59.1% | 6 | - | $1 | $33,672 | 18 | United International Pictures | false | false |
| 20 | 16 | 17 Again | $8 | -92.5% | 5 | - | $1 | $31,948 | 18 | Warner Bros. | false | false |
