| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | G.I. Joe: The Rise of Cobra | $317,308 | - | 74 | - | $4,287 | $317,308 | 1 | United International Pictures | true | false |
| 2 | - | My Sister's Keeper | $174,390 | - | 45 | - | $3,875 | $174,390 | 1 | NuMetro Distribution | true | false |
| 3 | 1 | G-Force | $109,366 | -30.8% | 65 | - | $1,682 | $619,672 | 3 | Ster-Kinekor Pictures | false | false |
| 4 | 2 | The Proposal | $92,812 | -35.4% | 65 | - | $1,427 | $1,875,571 | 6 | Ster-Kinekor Pictures | false | false |
| 5 | 5 | The Hangover | $49,087 | -31.6% | 55 | - | $892 | $1,667,183 | 9 | NuMetro Distribution | false | false |
| 6 | 3 | Harry Potter and the Half-Blood Prince | $47,466 | -48.4% | 71 | -11 | $668 | $1,571,397 | 5 | NuMetro Distribution | false | false |
| 7 | 4 | Ice Age: Dawn of the Dinosaurs | $43,809 | -43.9% | 67 | -13 | $653 | $3,095,107 | 7 | NuMetro Distribution | false | false |
| 8 | 6 | Fired Up! | $40,522 | -39.1% | 37 | - | $1,095 | $144,125 | 2 | Ster-Kinekor Pictures | false | false |
| 9 | 7 | My Life in Ruins | $32,201 | -39% | 35 | - | $920 | $231,268 | 3 | Ster-Kinekor Pictures | false | false |
| 10 | 10 | Fighting | $13,428 | -50.2% | 27 | -2 | $497 | $196,940 | 4 | United International Pictures | false | false |
| 11 | - | Disgrace | $12,828 | - | 10 | - | $1,282 | $12,828 | 1 | United International Pictures | true | false |
| 12 | 8 | Transformers: Revenge of the Fallen | $11,493 | -62% | 20 | -21 | $574 | $2,270,868 | 8 | United International Pictures | false | false |
| 13 | 9 | Love Aaj Kal | $11,155 | -59.4% | 7 | - | $1,593 | $88,973 | 3 | NuMetro Distribution | false | false |
| 14 | - | Kaminey | $10,967 | - | 5 | - | $2,193 | $10,967 | 1 | NuMetro Distribution | true | false |
| 15 | 13 | Virgin Territory | $9,907 | -27.3% | 10 | - | $990 | $33,251 | 2 | NuMetro Distribution | false | false |
| 16 | 11 | Knowing | $9,156 | -62% | 19 | -23 | $481 | $770,953 | 7 | United International Pictures | false | false |
| 17 | 14 | A Summer in Genoa | $7,664 | -42.4% | 10 | - | $766 | $30,146 | 2 | United International Pictures | false | false |
| 18 | 19 | Crossing Over | $5,772 | -20% | 9 | +1 | $641 | $67,584 | 5 | Ster-Kinekor Pictures | false | false |
| 19 | 16 | Management | $5,656 | -29.6% | 9 | - | $628 | $61,209 | 4 | NuMetro Distribution | false | false |
| 20 | 12 | Brüno | $5,637 | -61.3% | 17 | -15 | $331 | $387,513 | 6 | United International Pictures | false | false |
| 21 | 17 | Obsessed | $4,965 | -37.3% | 11 | - | $451 | $306,998 | 9 | Ster-Kinekor Pictures | false | false |
| 22 | 22 | The Brothers Bloom | $2,169 | -15% | 3 | -2 | $723 | $60,080 | 7 | Ster-Kinekor Pictures | false | false |
| 23 | - | The Song of Sparrows | $1,536 | - | 3 | - | $512 | $30,597 | 6 | Ster-Kinekor Pictures | false | false |
| 24 | 20 | Heaven on Earth | $1,529 | -62.7% | 4 | -1 | $382 | $15,761 | 3 | Ster-Kinekor Pictures | false | false |
