| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Harry Potter and the Half-Blood Prince | $680,557 | -21.5% | 203 | -9 | $3,352 | $13,710,707 | 5 | Warner Bros. | false | false |
| 2 | - | G.I. Joe: The Rise of Cobra | $454,499 | - | 81 | - | $5,611 | $475,549 | 1 | United International Pictures | true | false |
| 3 | 2 | Ice Age: Dawn of the Dinosaurs | $377,777 | -4.5% | 216 | -16 | $1,748 | $11,139,474 | 7 | 20th Century Fox International | false | false |
| 4 | 3 | Public Enemies | $254,177 | -30.1% | 80 | - | $3,177 | $1,691,351 | 3 | Universal Pictures International (UPI) | false | false |
| 5 | 4 | G-Force | $235,928 | -4.6% | 114 | +1 | $2,069 | $1,490,939 | 3 | Walt Disney Pictures | false | false |
| 6 | 5 | The Girl with the Dragon Tattoo | $144,356 | -10% | 35 | +5 | $4,124 | $431,632 | 2 | Benelux Film Distributors | false | false |
| 7 | 8 | The Proposal | $121,583 | -4.4% | 74 | -7 | $1,643 | $3,719,913 | 9 | Walt Disney Pictures | false | false |
| 8 | 7 | The Hangover | $112,527 | -12.5% | 64 | -1 | $1,758 | $4,455,806 | 10 | Warner Bros. | false | false |
| 9 | 6 | A Perfect Getaway | $104,454 | -27.5% | 54 | - | $1,934 | $362,748 | 2 | A-Film Distribution | false | false |
| 10 | 11 | Het geheim van Mega Mindy | $94,505 | +32% | 107 | +1 | $883 | $1,885,079 | 6 | Independent Films | false | false |
| 11 | 12 | Luke and Lucy: The Texas Rangers | $66,772 | +1.3% | 88 | - | $758 | $611,935 | 4 | RCV Film Distribution | false | false |
| 12 | - | The Indian | $65,516 | - | 70 | - | $935 | $161,211 | 1 | A-Film Distribution | true | false |
| 13 | 10 | Ghosts of Girlfriends Past | $63,393 | -22.1% | 50 | - | $1,267 | $884,834 | 4 | RCV Film Distribution | false | false |
| 14 | 9 | Brüno | $44,794 | -47.6% | 59 | -25 | $759 | $2,871,243 | 6 | Universal Pictures International (UPI) | false | false |
| 15 | - | Away We Go | $28,662 | - | 16 | - | $1,791 | $33,854 | 1 | A-Film Distribution | true | false |
| 16 | - | Crossing Over | $19,295 | - | 14 | - | $1,378 | $24,463 | 1 | Paradiso Entertainment | true | false |
| 17 | 15 | Angels & Demons | $17,894 | -16% | 21 | +1 | $852 | $7,909,763 | 14 | Sony Pictures Releasing | false | false |
| 18 | 18 | Sunshine Barry and the Disco Worms | $15,271 | +0.2% | 50 | -5 | $305 | $108,546 | 3 | Independent Films | false | false |
| 19 | 13 | Transformers: Revenge of the Fallen | $12,365 | -53.2% | 8 | -11 | $1,545 | $3,730,164 | 8 | Universal Pictures International (UPI) | false | false |
| 20 | 16 | The Private Lives of Pippa Lee | $10,055 | -39.6% | 12 | - | $837 | $81,784 | 3 | RCV Film Distribution | false | false |
