| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | G.I. Joe: The Rise of Cobra | $1,054,443 | - | 89 | - | $11,847 | $1,161,318 | 1 | United International Pictures | true | false |
| 2 | 1 | The Proposal | $242,372 | -45.5% | 50 | - | $4,847 | $818,329 | 2 | Walt Disney Pictures | false | false |
| 3 | 2 | Harry Potter and the Half-Blood Prince | $129,600 | -56.2% | 105 | - | $1,234 | $3,883,750 | 4 | Warner Bros. | false | false |
| 4 | 3 | Oh, My Girl!: A Laugh Story... | $118,602 | -45.2% | 70 | -2 | $1,694 | $384,936 | 2 | N/A | false | false |
| 5 | 4 | Orphan | $63,095 | -29.5% | 30 | - | $2,103 | $180,005 | 2 | Warner Bros. | false | false |
| 6 | 5 | Ice Age: Dawn of the Dinosaurs | $28,983 | -66.3% | 33 | -7 | $878 | $2,386,840 | 6 | 20th Century Fox International | false | false |
| 7 | 9 | It's Alive | $24,428 | +17.6% | 18 | - | $1,357 | $127,154 | 3 | Viva International Pictures | false | false |
| 8 | 6 | Public Enemies | $16,223 | -68.3% | 13 | -3 | $1,247 | $229,271 | 3 | United International Pictures | false | false |
| 9 | 7 | Nothing But the Truth | $15,834 | -38.6% | 16 | - | $989 | $47,586 | 2 | Pioneer Films | false | false |
| 10 | 8 | Transformers: Revenge of the Fallen | $11,206 | -56.6% | 17 | -6 | $659 | $7,375,065 | 7 | United International Pictures | false | false |
| 11 | 11 | My Sister's Keeper | $6,284 | -15.6% | 10 | -5 | $628 | $49,667 | 3 | Pioneer Films | false | false |
| 12 | 10 | Hannah Montana: The Movie | $5,926 | -29.3% | 11 | +2 | $538 | $239,328 | 5 | Walt Disney Pictures | false | false |
| 13 | 12 | The Taking of Pelham 123 | $471 | -78.4% | 2 | -1 | $235 | $520,319 | 2 | Sony Pictures Releasing | false | false |
