| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Harry Potter and the Half-Blood Prince | $1,376,725 | -31.7% | 215 | -4 | $6,403 | $11,009,262 | 3 | Warner Bros. | false | false |
| 2 | 2 | Ice Age: Dawn of the Dinosaurs | $752,020 | -17.5% | 239 | -2 | $3,146 | $9,717,238 | 5 | 20th Century Fox International | false | false |
| 3 | - | Public Enemies | $624,807 | - | 80 | - | $7,810 | $665,144 | 1 | Universal Pictures International (UPI) | true | false |
| 4 | - | G-Force | $438,404 | - | 111 | - | $3,949 | $536,031 | 1 | Walt Disney Pictures | true | false |
| 5 | 5 | The Proposal | $177,135 | -14.6% | 82 | - | $2,160 | $3,304,773 | 7 | Walt Disney Pictures | false | false |
| 6 | 7 | Het geheim van Mega Mindy | $173,873 | -2.9% | 106 | -1 | $1,640 | $1,540,194 | 4 | Independent Films | false | false |
| 7 | 3 | Brüno | $170,286 | -39.7% | 92 | -2 | $1,850 | $2,622,964 | 4 | Universal Pictures International (UPI) | false | false |
| 8 | 6 | The Hangover | $154,001 | -25.5% | 65 | -1 | $2,369 | $4,076,725 | 8 | Warner Bros. | false | false |
| 9 | 8 | Luke and Lucy: The Texas Rangers | $131,755 | +6.6% | 88 | +1 | $1,497 | $343,553 | 2 | RCV Film Distribution | false | false |
| 10 | 4 | Ghosts of Girlfriends Past | $130,004 | -38.1% | 50 | - | $2,600 | $624,612 | 2 | RCV Film Distribution | false | false |
| 11 | 9 | Transformers: Revenge of the Fallen | $49,106 | -48.6% | 29 | -34 | $1,693 | $3,662,567 | 6 | Universal Pictures International (UPI) | false | false |
| 12 | - | Sunshine Barry and the Disco Worms | $39,503 | - | 55 | - | $718 | $39,503 | 1 | Independent Films | true | false |
| 13 | 11 | Angels & Demons | $33,159 | -38.6% | 26 | -17 | $1,275 | $7,862,062 | 12 | Sony Pictures Releasing | false | false |
| 14 | 10 | Drag Me to Hell | $31,243 | -42.8% | 13 | -6 | $2,403 | $684,840 | 5 | RCV Film Distribution | false | false |
| 15 | - | The Private Lives of Pippa Lee | $25,307 | - | 12 | - | $2,108 | $31,707 | 1 | RCV Film Distribution | true | false |
| 16 | 12 | Coco Before Chanel | $24,207 | -8.8% | 25 | -1 | $968 | $946,499 | 10 | RCV Film Distribution | false | false |
| 17 | - | Welcome | $17,275 | - | 8 | - | $2,159 | $19,572 | 1 | Cinéart | true | false |
| 18 | 13 | Ponyo | $12,895 | -27.9% | 42 | - | $307 | $42,620 | 2 | Wild Bunch Distribution | false | false |
| 19 | 15 | A Summer in Genoa | $11,635 | -10.1% | 7 | - | $1,662 | $98,923 | 4 | A-Film Distribution | false | false |
| 20 | - | Vampire Killers | $10,692 | - | 1 | - | $10,692 | $33,484 | 1 | - | true | false |
| 21 | 21 | Terminator Salvation | $375 | -83.2% | 2 | -1 | $187 | $2,116,160 | 9 | Sony Pictures Releasing | false | false |
