| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Ice Age: Dawn of the Dinosaurs | $606,900 | -19.1% | 106 | +6 | $5,725 | $13,565,742 | 6 | 20th Century Fox International | false | false |
| 2 | 4 | The Hangover | $440,714 | +2.6% | 50 | +2 | $8,814 | $2,342,420 | 7 | Warner Bros. | false | false |
| 3 | 3 | The Proposal | $387,256 | -13.5% | 55 | - | $7,041 | $1,144,822 | 2 | Walt Disney Pictures | false | false |
| 4 | 2 | Harry Potter and the Half-Blood Prince | $378,496 | -26.7% | 104 | -8 | $3,639 | $5,789,680 | 4 | Warner Bros. | false | false |
| 5 | 5 | Up | $253,822 | -28.6% | 31 | - | $8,187 | $803,785 | 2 | Walt Disney Pictures | false | false |
| 6 | - | G.I. Joe: The Rise of Cobra | $218,291 | - | 50 | - | $4,365 | $241,384 | 1 | Universal Pictures International (UPI) | true | false |
| 7 | 6 | Public Enemies | $204,664 | -21.7% | 51 | +3 | $4,013 | $952,329 | 5 | Universal Pictures International (UPI) | false | false |
| 8 | 7 | Brüno | $75,456 | -38.9% | 51 | -8 | $1,479 | $2,296,045 | 3 | N/A | false | false |
| 9 | 8 | The Taking of Pelham 123 | $65,412 | -23.1% | 14 | - | $4,672 | $203,863 | 2 | Sony Pictures Releasing | false | false |
| 10 | - | Maria, He Doesn't Like It | $40,351 | - | 8 | - | $5,043 | $40,351 | 1 | N/A | true | false |
| 11 | 12 | Angels & Demons | $26,114 | +309.8% | 4 | +3 | $6,528 | $4,383,490 | 13 | Sony Pictures Releasing | false | false |
| 12 | 9 | Everyone Else | $18,937 | -1.8% | 7 | -2 | $2,705 | $247,804 | 6 | N/A | false | false |
| 13 | - | Looking for Eric | $16,103 | - | 2 | - | $8,051 | $161,903 | 9 | N/A | false | false |
| 14 | - | Sunshine Cleaning | $13,061 | - | 3 | - | $4,353 | $76,858 | 1 | N/A | true | false |
