| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Ice Age: Dawn of the Dinosaurs | $62,506 | -41.3% | 21 | - | $2,976 | $961,132 | 4 | 20th Century Fox International | false | false |
| 2 | 2 | Harry Potter and the Half-Blood Prince | $31,226 | -57.8% | 10 | - | $3,122 | $192,057 | 2 | Warner Bros. | false | false |
| 3 | 3 | Brüno | $25,222 | -50.7% | 10 | - | $2,522 | $269,715 | 3 | N/A | false | false |
| 4 | 4 | The Hangover | $9,053 | -34.4% | 6 | - | $1,508 | $286,175 | 7 | Warner Bros. | false | false |
| 5 | - | The Last House on the Left | $8,023 | - | 7 | - | $1,146 | $9,877 | 1 | United International Pictures | true | false |
| 6 | - | Two Lovers | $3,234 | - | 2 | - | $1,617 | $3,828 | 1 | N/A | true | false |
| 7 | 5 | Drag Me to Hell | $2,591 | -44.9% | 4 | - | $647 | $54,083 | 5 | Walt Disney Pictures | false | false |
| 8 | 7 | Angels & Demons | $1,836 | -36% | 2 | - | $918 | $452,636 | 11 | Sony Pictures Releasing | false | false |
| 9 | 6 | Transformers: Revenge of the Fallen | $1,754 | -60.8% | 5 | - | $350 | $93,702 | 5 | United International Pictures | false | false |
| 10 | 8 | Hannah Montana: The Movie | $1,186 | -46.8% | 8 | - | $148 | $96,163 | 6 | Walt Disney Pictures | false | false |
| 11 | 10 | Fighting | $1,010 | +12.3% | 6 | - | $168 | $42,367 | 6 | United International Pictures | false | false |
| 12 | 9 | Knowing | $351 | -64.9% | 3 | - | $117 | $22,672 | 6 | N/A | false | false |
