| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Harry Potter and the Half-Blood Prince | $1,340,597 | - | 120 | - | $11,171 | $2,204,484 | 1 | Warner Bros. | true | false |
| 2 | 1 | Ice Age: Dawn of the Dinosaurs | $1,033,120 | -29.2% | 93 | -11 | $11,108 | $6,170,766 | 3 | 20th Century Fox International | false | false |
| 3 | 2 | Transformers: Revenge of the Fallen | $226,850 | -38.1% | 58 | +8 | $3,911 | $3,574,357 | 4 | United International Pictures | false | false |
| 4 | 3 | Up | $173,238 | -46.3% | 56 | -10 | $3,093 | $6,855,570 | 7 | Walt Disney Pictures | false | false |
| 5 | 4 | The Last House on the Left | $86,978 | -39.2% | 32 | -2 | $2,718 | $332,097 | 2 | United International Pictures | false | false |
| 6 | 5 | Push | $53,745 | -40.7% | 18 | -1 | $2,985 | $208,548 | 15 | N/A | false | false |
| 7 | 6 | The Unborn | $32,325 | -59.9% | 15 | -15 | $2,155 | $1,557,554 | 6 | United International Pictures | false | false |
| 8 | 7 | The Other Boleyn Girl | $24,926 | -40.6% | 6 | -12 | $4,154 | $100,990 | 2 | N/A | false | false |
| 9 | - | The Wrestler | $19,062 | - | 5 | - | $3,812 | $33,707 | 1 | N/A | true | false |
| 10 | 11 | Impy's Island | $16,664 | -29.1% | 10 | -6 | $1,666 | $190,396 | 4 | N/A | false | false |
| 11 | 10 | Night at the Museum: Battle of the Smithsonian | $12,206 | -58% | 11 | -5 | $1,109 | $4,338,386 | 9 | 20th Century Fox International | false | false |
| 12 | 9 | Duplicity | $9,770 | -70.1% | 9 | -9 | $1,085 | $603,189 | 5 | United International Pictures | false | false |
| 13 | 12 | War | $7,850 | -62.4% | 2 | -8 | $3,925 | $233,319 | 5 | N/A | false | false |
| 14 | 8 | Terminator Salvation | $6,661 | -82.8% | 7 | -13 | $951 | $2,663,824 | 7 | Sony Pictures Releasing | false | false |
| 15 | 13 | In Bruges | $6,130 | -66.2% | 3 | -2 | $2,043 | $149,885 | 5 | N/A | false | false |
| 16 | 15 | Angels & Demons | $823 | -94.7% | 2 | -8 | $411 | $4,443,764 | 10 | Sony Pictures Releasing | false | false |
| 17 | 14 | The Air I Breathe | $84 | -99.5% | 1 | -6 | $84 | $107,013 | 4 | N/A | false | false |
