| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Harry Potter and the Half-Blood Prince | $1,549,210 | - | 93 | - | $16,658 | $2,022,368 | 1 | Warner Bros. | true | false |
| 2 | 1 | Ice Age: Dawn of the Dinosaurs | $550,662 | -25.4% | 88 | - | $6,257 | $3,032,988 | 3 | 20th Century Fox International | false | false |
| 3 | 2 | Transformers: Revenge of the Fallen | $320,908 | -37% | 88 | -9 | $3,646 | $4,681,312 | 4 | Paramount Pictures International | false | false |
| 4 | 3 | Brüno | $245,117 | -50.4% | 50 | - | $4,902 | $1,068,123 | 2 | United International Pictures | false | false |
| 5 | 4 | Hannah Montana: The Movie | $200,750 | -17.9% | 80 | - | $2,509 | $1,109,829 | 4 | Walt Disney Pictures | false | false |
| 6 | 6 | The Hangover | $72,598 | -44% | 38 | -6 | $1,910 | $1,657,094 | 6 | Warner Bros. | false | false |
| 7 | 5 | The Proposal | $72,114 | -46.3% | 40 | -6 | $1,802 | $1,310,633 | 5 | Walt Disney Pictures | false | false |
| 8 | - | My Life in Ruins | $53,327 | - | 25 | - | $2,133 | $53,327 | 1 | 20th Century Fox International | true | false |
| 9 | - | Phèdre | $26,816 | - | 16 | - | $1,676 | $26,816 | 1 | Rialto Distribution | true | false |
| 10 | 14 | The Sicilian Girl | $13,049 | -11.5% | 12 | +4 | $1,087 | $33,259 | 2 | Vendetta Films | false | false |
| 11 | 9 | Easy Virtue | $12,779 | -42.7% | 24 | - | $532 | $539,100 | 8 | Hopscotch Films | false | false |
| 12 | 15 | I've Loved You So Long | $11,280 | -11.7% | 11 | +2 | $1,025 | $278,217 | 10 | Palace Films | false | false |
| 13 | 8 | Night at the Museum: Battle of the Smithsonian | $10,657 | -53.4% | 20 | -24 | $532 | $1,506,291 | 9 | 20th Century Fox International | false | false |
| 14 | 11 | Bride Flight | $9,952 | -38.5% | 22 | -1 | $452 | $105,810 | 4 | Hopscotch Films | false | false |
| 15 | 12 | A Bunch of Amateurs | $6,794 | -57.1% | 30 | - | $226 | $145,301 | 114 | Rialto Distribution | false | false |
| 16 | 7 | Kambakkht Ishq | $6,068 | -74.5% | 5 | -1 | $1,213 | $36,730 | 2 | - | false | false |
| 17 | 20 | Gomorrah | $4,179 | -10.7% | 5 | +3 | $835 | $48,472 | 5 | Madman Entertainment | false | false |
| 18 | 13 | Angels & Demons | $4,172 | -72.7% | 11 | -6 | $379 | $1,933,969 | 10 | Sony Pictures Releasing | false | false |
| 19 | 10 | Terminator Salvation | $3,306 | -84.6% | 10 | -17 | $330 | $1,628,769 | 7 | Sony Pictures Releasing | false | false |
| 20 | 18 | The Reader | $3,019 | -45.6% | 13 | +1 | $232 | $830,493 | 15 | Roadshow Films | false | false |
