| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Harry Potter and the Half-Blood Prince | $6,660,905 | - | 1,009 | - | $6,601 | $9,461,712 | 1 | Warner Bros. | true | false |
| 2 | 1 | Ice Age: Dawn of the Dinosaurs | $3,471,718 | -44.5% | 643 | -327 | $5,399 | $30,265,939 | 3 | 20th Century Fox International | false | false |
| 3 | 2 | Transformers: Revenge of the Fallen | $556,403 | -53.3% | 447 | -28 | $1,244 | $17,475,048 | 4 | Paramount Pictures International | false | false |
| 4 | 3 | Public Enemies | $495,754 | -39.9% | 365 | -33 | $1,358 | $3,938,585 | 3 | Universal Pictures International (UPI) | false | false |
| 5 | 4 | The Proposal | $207,930 | -47.8% | 199 | -116 | $1,044 | $6,084,668 | 5 | Walt Disney Pictures | false | false |
| 6 | 5 | All Inclusive | $186,210 | -51.9% | 227 | -23 | $820 | $899,573 | 2 | Universal Pictures International (UPI) | false | false |
| 7 | 7 | My Sister's Keeper | $161,461 | -18.2% | 125 | -36 | $1,291 | $1,725,863 | 4 | Warner Bros. | false | false |
| 8 | 6 | The Code | $111,150 | -54.9% | 167 | -34 | $665 | $538,569 | 2 | Gussi Films | false | false |
| 9 | - | It's Alive | $50,165 | - | 60 | - | $836 | $58,769 | 1 | Gussi Films | true | false |
| 10 | 8 | 17 Again | $45,408 | -71.9% | 83 | -66 | $547 | $2,355,525 | 5 | Gussi Films | false | false |
| 11 | 10 | Up | $42,799 | -65.1% | 98 | -137 | $436 | $14,097,100 | 7 | Walt Disney Pictures | false | false |
| 12 | 9 | Night at the Museum: Battle of the Smithsonian | $41,157 | -70.9% | 91 | -167 | $452 | $10,009,438 | 6 | 20th Century Fox International | false | false |
| 13 | 11 | Smother | $20,502 | -73.3% | 57 | -23 | $359 | $151,881 | 2 | Videocine | false | false |
| 14 | 13 | Gomorrah | $17,295 | -13.7% | 9 | - | $1,921 | $50,443 | 2 | N/A | false | false |
| 15 | - | Waltz with Bashir | $12,414 | - | 10 | - | $1,241 | $13,958 | 1 | N/A | true | false |
| 16 | 12 | Push | $9,752 | -75.1% | 20 | -22 | $487 | $837,940 | 18 | N/A | false | false |
| 17 | 18 | Happy-Go-Lucky | $9,315 | -6.4% | 9 | +1 | $1,035 | $90,058 | 4 | N/A | false | false |
| 18 | 14 | State of Play | $7,193 | -51.5% | 15 | -13 | $479 | $1,603,166 | 7 | Universal Pictures International (UPI) | false | false |
| 19 | 17 | Angels & Demons | $4,192 | -67.9% | 14 | -10 | $299 | $13,373,473 | 10 | Sony Pictures Releasing | false | false |
| 20 | 20 | The Last House on the Left | $3,302 | -53.7% | 14 | -3 | $235 | $445,028 | 9 | Universal Pictures International (UPI) | false | false |
| 21 | 26 | Three Monkeys | $2,763 | -16.9% | 1 | - | $2,763 | $37,546 | 6 | N/A | false | false |
| 22 | 16 | Religulous | $2,733 | -79.4% | 5 | -21 | $546 | $26,461 | 2 | N/A | false | false |
| 23 | 29 | Blame it on Fidel | $2,352 | +37.1% | 5 | +1 | $470 | $36,534 | 4 | N/A | false | false |
| 24 | 22 | Rachel Getting Married | $1,957 | -56.7% | 5 | -1 | $391 | $153,884 | 18 | Sony Pictures Releasing | false | false |
| 25 | 19 | Hannah Montana: The Movie | $1,876 | -75% | 7 | -7 | $268 | $2,455,662 | 9 | Walt Disney Pictures | false | false |
| 26 | 25 | I'm Gonna Explode | $1,868 | -47.5% | 19 | -1 | $98 | $52,224 | 114 | Videocine | false | false |
| 27 | 28 | X-Men Origins: Wolverine | $1,508 | -39.6% | 9 | -2 | $167 | $10,267,814 | 12 | 20th Century Fox International | false | false |
| 28 | 21 | Personal Effects | $1,392 | -77.8% | 4 | -3 | $348 | $94,127 | 8 | Gussi Films | false | false |
| 29 | 30 | The Band's Visit | $760 | -51.9% | 3 | - | $253 | $62,504 | 7 | N/A | false | false |
| 30 | 24 | Star Trek | $336 | -90.7% | 5 | -12 | $67 | $3,415,128 | 11 | Paramount Pictures International | false | false |
