| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Transformers: Revenge of the Fallen | $42,500,000 | $42,320,877 | -$179,123 | -0.4% | 4,234 | $293,459,000 | $293,355,885 | 2 | DreamWorks | - |
| 2 | 2 | - | Ice Age: Dawn of the Dinosaurs | $42,500,000 | $41,690,382 | -$809,618 | -1.9% | 4,099 | $67,506,000 | $66,732,868 | 1 | Twentieth Century Fox | - |
| 3 | 3 | - | Public Enemies | $26,172,000 | $25,271,675 | -$900,325 | -3.4% | 3,334 | $41,044,000 | $40,141,080 | 1 | Universal Pictures | - |
| 4 | 4 | - | The Proposal | $12,779,000 | $12,857,482 | +$78,482 | +0.6% | 3,099 | $94,233,000 | $94,335,111 | 3 | Walt Disney Studios Motion Pictures | - |
| 5 | 5 | - | The Hangover | $10,415,000 | $11,268,413 | +$853,413 | +8.2% | 3,070 | $204,197,000 | $205,038,233 | 5 | Warner Bros. | - |
| 6 | 6 | - | Up | $6,579,000 | $6,521,389 | -$57,611 | -0.9% | 2,656 | $264,873,000 | $264,816,694 | 6 | Walt Disney Studios Motion Pictures | - |
| 7 | 7 | - | My Sister's Keeper | $5,255,000 | $5,788,327 | +$533,327 | +10.1% | 2,606 | $25,964,000 | $26,518,582 | 2 | Warner Bros. | - |
| 8 | 8 | - | The Taking of Pelham 123 | $2,500,000 | $2,534,228 | +$34,228 | +1.4% | 1,908 | $58,471,000 | $58,508,070 | 4 | Sony Pictures Releasing | - |
| 9 | 9 | - | Year One | $2,100,000 | $2,323,843 | +$223,843 | +10.7% | 2,240 | $38,088,000 | $38,304,392 | 3 | Sony Pictures Releasing | - |
| 10 | 10 | - | Night at the Museum: Battle of the Smithsonian | $2,100,000 | $2,043,288 | -$56,712 | -2.7% | 1,419 | $167,763,000 | $167,706,959 | 7 | Twentieth Century Fox | - |
| 11 | 11 | - | Star Trek | $1,815,000 | $1,769,967 | -$45,033 | -2.5% | 1,148 | $249,847,000 | $249,838,139 | 9 | Paramount Pictures | - |
| 12 | 12 | - | Away We Go | $1,100,000 | $1,096,212 | -$3,788 | -0.3% | 506 | $6,074,000 | $6,077,303 | 5 | Focus Features | - |
| 13 | 13 | - | Whatever Works | $1,067,000 | $960,061 | -$106,939 | -10% | 353 | $2,017,000 | $1,911,001 | 3 | Sony Pictures Classics | - |
| 14 | 16 | +2 | Chéri | $388,000 | $388,994 | +$994 | +0.3% | 140 | $1,024,000 | $1,023,909 | 2 | Miramax | - |
| 15 | 19 | +4 | X-Men Origins: Wolverine | $315,000 | $296,352 | -$18,648 | -5.9% | 303 | $178,358,000 | $178,341,745 | 10 | Twentieth Century Fox | - |
| 16 | 22 | +6 | Moon | $300,000 | $262,583 | -$37,417 | -12.5% | 47 | $983,000 | $945,279 | 4 | Sony Pictures Classics | - |
| 17 | 18 | +1 | Terminator Salvation | $296,000 | $296,372 | +$372 | +0.1% | 311 | $122,700,000 | $122,678,310 | 7 | Warner Bros. | - |
| 18 | 17 | -1 | Land of the Lost | $293,000 | $306,025 | +$13,025 | +4.4% | 385 | $47,613,000 | $47,622,470 | 5 | Universal Pictures | - |
| 19 | 20 | +1 | Imagine That | $285,000 | $278,244 | -$6,756 | -2.4% | 409 | $14,786,000 | $14,780,593 | 4 | Paramount Pictures | - |
| 20 | 25 | +5 | Drag Me to Hell | $258,000 | $250,335 | -$7,665 | -3% | 298 | $41,063,000 | $41,054,455 | 6 | Universal Pictures | - |
| 21 | 23 | +2 | Monsters vs. Aliens | $251,000 | $258,355 | +$7,355 | +2.9% | 281 | $196,553,000 | $196,564,095 | 15 | DreamWorks | - |
| 22 | 24 | +2 | Food, Inc. | $240,000 | $251,684 | +$11,684 | +4.9% | 83 | $1,275,000 | $1,286,693 | 4 | Magnolia Pictures | - |
| 23 | 28 | +5 | The Hurt Locker | $126,000 | $131,202 | +$5,202 | +4.1% | 9 | $365,000 | $370,123 | 2 | Summit Entertainment | - |
| 24 | 31 | +7 | Easy Virtue | $106,000 | $105,949 | -$51 | <0.1% | 95 | $2,266,000 | $2,272,691 | 7 | Sony Pictures Classics | - |
| 25 | 33 | +8 | La fille de Monaco | $90,000 | $83,755 | -$6,245 | -6.9% | 21 | $90,000 | $83,755 | 1 | Magnolia Pictures | - |
| 26 | 36 | +10 | Dance Flick | $74,000 | $70,734 | -$3,266 | -4.4% | 85 | $25,281,000 | $25,277,770 | 7 | Paramount Pictures | - |
| 27 | 35 | +8 | The Stoning of Soraya M. | $73,800 | $74,441 | +$641 | +0.9% | 25 | $293,000 | $248,974 | 2 | Roadside Attractions | - |
| 28 | 34 | +6 | The Brothers Bloom | $73,000 | $75,776 | +$2,776 | +3.8% | 153 | $3,267,000 | $3,270,242 | 8 | Summit Entertainment | - |
| 29 | 38 | +9 | The Soloist | $71,000 | $69,114 | -$1,886 | -2.7% | 156 | $31,673,000 | $31,670,931 | 11 | DreamWorks | - |
| 30 | 43 | +13 | Tetro | $26,900 | $27,816 | +$916 | +3.4% | 11 | $235,000 | $235,630 | 4 | American Zoetrope | - |
| 31 | 44 | +13 | Every Little Step | $24,600 | $27,468 | +$2,868 | +11.7% | 26 | $1,476,000 | $1,477,126 | 12 | Sony Pictures Classics | - |
| 32 | 57 | +25 | Herb & Dorothy | $7,900 | $7,692 | -$208 | -2.6% | 4 | $71,900 | $71,699 | 5 | Arthouse Films | - |
| 33 | 68 | +35 | Sin Nombre | $3,880 | $3,876 | -$4 | -0.1% | 12 | $2,528,000 | $2,527,470 | 16 | Focus Features | - |
