| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Ice Age: Dawn of the Dinosaurs | $9,162,498 | - | 970 | - | $9,445 | $9,687,742 | 1 | 20th Century Fox International | true | false |
| 2 | 1 | Transformers: Revenge of the Fallen | $2,239,433 | -56.2% | 475 | -433 | $4,714 | $13,545,125 | 2 | Paramount Pictures International | false | false |
| 3 | - | Public Enemies | $1,144,290 | - | 398 | - | $2,875 | $1,144,290 | 1 | Universal Pictures International (UPI) | true | false |
| 4 | 4 | The Proposal | $600,475 | -35.8% | 403 | -30 | $1,490 | $4,699,669 | 3 | Walt Disney Pictures | false | false |
| 5 | 3 | Night at the Museum: Battle of the Smithsonian | $303,484 | -70.2% | 413 | -42 | $734 | $9,488,555 | 4 | 20th Century Fox International | false | false |
| 6 | 7 | My Sister's Keeper | $276,309 | -21.1% | 198 | -1 | $1,395 | $963,427 | 2 | Warner Bros. | false | false |
| 7 | 2 | Up | $237,942 | -77.5% | 381 | -370 | $624 | $13,656,486 | 5 | Walt Disney Pictures | false | false |
| 8 | 6 | 17 Again | $152,429 | -62.8% | 207 | -102 | $736 | $1,892,688 | 3 | Gussi Films | false | false |
| 9 | 8 | Angels & Demons | $48,336 | -74.5% | 85 | -223 | $568 | $13,316,629 | 8 | Sony Pictures Releasing | false | false |
| 10 | 15 | Happy-Go-Lucky | $19,182 | -5.2% | 11 | +1 | $1,743 | $54,397 | 2 | N/A | false | false |
| 11 | 11 | State of Play | $18,721 | -65.8% | 26 | -49 | $720 | $1,553,479 | 5 | Universal Pictures International (UPI) | false | false |
| 12 | 10 | Star Trek | $17,176 | -84.2% | 46 | -179 | $373 | $3,393,639 | 9 | Paramount Pictures International | false | false |
| 13 | 12 | Hannah Montana: The Movie | $10,936 | -67.3% | 28 | -33 | $390 | $2,426,341 | 7 | Walt Disney Pictures | false | false |
| 14 | 9 | X-Men Origins: Wolverine | $9,667 | -92.8% | 17 | -263 | $568 | $10,251,306 | 10 | 20th Century Fox International | false | false |
| 15 | 16 | Ghosts of Girlfriends Past | $9,237 | -43.8% | 17 | -11 | $543 | $2,727,523 | 8 | Warner Bros. | false | false |
| 16 | 17 | Blame it on Fidel | $8,545 | -20.1% | 6 | -3 | $1,424 | $26,461 | 2 | N/A | false | false |
| 17 | 13 | Push | $5,509 | -75.4% | 11 | -26 | $500 | $754,094 | 16 | N/A | false | false |
| 18 | 24 | Three Monkeys | $4,055 | +1% | 3 | - | $1,351 | $26,714 | 4 | N/A | false | false |
| 19 | 23 | The Band's Visit | $3,554 | -11.9% | 10 | +1 | $355 | $56,443 | 5 | N/A | false | false |
| 20 | 21 | Then She Found Me | $3,491 | -26.8% | 12 | +1 | $290 | $151,899 | 8 | Videocine | false | false |
| 21 | 14 | The Last House on the Left | $3,047 | -86.4% | 8 | -38 | $380 | $423,266 | 7 | Universal Pictures International (UPI) | false | false |
| 22 | 18 | Sin Nombre | $2,960 | -62.5% | 6 | -11 | $493 | $605,163 | 8 | Universal Pictures International (UPI) | false | false |
| 23 | 27 | Rachel Getting Married | $1,285 | +17.4% | 3 | -1 | $428 | $142,523 | 16 | Sony Pictures Releasing | false | false |
| 24 | 22 | I'm Gonna Explode | $949 | -78.4% | 1 | -39 | $949 | $42,866 | 112 | Videocine | false | false |
| 25 | 28 | 3:19 | $767 | -25.7% | 1 | -3 | $767 | $32,527 | 112 | N/A | false | false |
| 26 | 26 | Earth | $344 | -70.3% | 2 | -9 | $172 | $948,479 | 8 | Walt Disney Pictures | false | false |
| 27 | 25 | Personal Effects | $238 | -93.9% | 2 | -2 | $119 | $81,804 | 6 | Gussi Films | false | false |
