| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Transformers: Revenge of the Fallen | $11,011,087 | - | 457 | - | $24,094 | $13,147,155 | 1 | Paramount Pictures International | true | false |
| 2 | 1 | The Proposal | $1,899,442 | -32.6% | 280 | - | $6,783 | $6,213,924 | 2 | Walt Disney Pictures | false | false |
| 3 | 2 | The Hangover | $1,809,478 | -30.2% | 227 | - | $7,971 | $9,126,594 | 3 | Warner Bros. | false | false |
| 4 | - | Hannah Montana: The Movie | $799,742 | - | 136 | - | $5,880 | $1,110,213 | 1 | Walt Disney Pictures | true | false |
| 5 | 3 | Year One | $720,134 | -54.5% | 185 | - | $3,892 | $2,701,556 | 2 | Sony Pictures Releasing | false | false |
| 6 | 4 | Terminator Salvation | $425,336 | -59.9% | 279 | -65 | $1,524 | $11,355,650 | 4 | Sony Pictures Releasing | false | false |
| 7 | 6 | Night at the Museum: Battle of the Smithsonian | $328,522 | -47.5% | 208 | -56 | $1,579 | $12,870,280 | 6 | 20th Century Fox International | false | false |
| 8 | - | Coco Before Chanel | $306,952 | - | 26 | - | $11,805 | $306,952 | 1 | Roadshow Films | true | false |
| 9 | 5 | Land of the Lost | $284,012 | -61.8% | 196 | -23 | $1,449 | $2,763,773 | 3 | Universal Pictures International (UPI) | false | false |
| 10 | 7 | State of Play | $183,283 | -50.5% | 114 | -89 | $1,607 | $5,232,410 | 5 | Universal Pictures International (UPI) | false | false |
| 11 | 8 | Angels & Demons | $165,029 | -52.7% | 120 | -101 | $1,375 | $14,229,281 | 7 | Sony Pictures Releasing | false | false |
| 12 | 11 | Disgrace | $123,231 | -26.8% | 26 | +2 | $4,739 | $357,934 | 2 | Icon Film Distribution | false | false |
| 13 | - | New York | $105,089 | - | 10 | - | $10,508 | $105,089 | 1 | Mind Blowing Films | true | false |
| 14 | 9 | I Love You, Man | $91,708 | -68.6% | 99 | -87 | $926 | $3,487,256 | 4 | Paramount Pictures International | false | false |
| 15 | 10 | Star Trek | $87,566 | -55.6% | 77 | -44 | $1,137 | $12,733,507 | 8 | Paramount Pictures International | false | false |
| 16 | 13 | Samson & Delilah | $83,787 | -29.3% | 31 | -7 | $2,702 | $1,940,593 | 8 | Paramount Pictures International | false | false |
| 17 | 12 | Sunshine Cleaning | $81,683 | -37.4% | 55 | - | $1,485 | $541,907 | 3 | Madman Entertainment | false | false |
| 18 | 15 | My Year Without Sex | $40,156 | -33.1% | 22 | -1 | $1,825 | $661,020 | 6 | Paramount Pictures International | false | false |
| 19 | 14 | Is Anybody There? | $30,575 | -50.3% | 35 | -7 | $873 | $456,345 | 4 | Hopscotch Films | false | false |
| 20 | - | Wake in Fright | $20,531 | - | 4 | - | $5,132 | $22,461 | 1 | Madman Entertainment | true | false |
| 21 | - | Thirst | $2,327 | - | 1 | - | $2,327 | $2,327 | 1 | Madman Entertainment | true | false |
