| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Hangover | $225,114 | - | 55 | - | $4,092 | $225,114 | 1 | NuMetro Distribution | true | false |
| 2 | 1 | Night at the Museum: Battle of the Smithsonian | $91,576 | -40.8% | 81 | +1 | $1,130 | $1,132,095 | 5 | NuMetro Distribution | false | false |
| 3 | 2 | Terminator Salvation | $71,724 | -47.4% | 79 | - | $907 | $649,876 | 3 | Ster-Kinekor Pictures | false | false |
| 4 | 3 | Ghosts of Girlfriends Past | $43,673 | -45.8% | 47 | - | $929 | $758,040 | 6 | NuMetro Distribution | false | false |
| 5 | - | Obsessed | $40,220 | - | 24 | - | $1,675 | $40,220 | 1 | Ster-Kinekor Pictures | true | false |
| 6 | 5 | Drag Me to Hell | $39,955 | -42.9% | 40 | - | $998 | $167,282 | 2 | NuMetro Distribution | false | false |
| 7 | 4 | State of Play | $38,194 | -47.5% | 31 | - | $1,232 | $172,386 | 2 | United International Pictures | false | false |
| 8 | 6 | Duplicity | $36,689 | -45.1% | 43 | - | $853 | $462,862 | 4 | United International Pictures | false | false |
| 9 | 7 | Angels & Demons | $29,638 | -52.4% | 57 | -14 | $519 | $970,358 | 6 | Ster-Kinekor Pictures | false | false |
| 10 | 8 | 17 Again | $13,994 | -46.9% | 33 | -10 | $424 | $1,219,615 | 10 | NuMetro Distribution | false | false |
| 11 | 11 | Sunshine Cleaning | $10,127 | -38.9% | 10 | - | $1,012 | $40,289 | 2 | United International Pictures | false | false |
| 12 | 10 | Hannah Montana: The Movie | $9,006 | -53% | 25 | -7 | $360 | $710,484 | 8 | Ster-Kinekor Pictures | false | false |
| 13 | 9 | X-Men Origins: Wolverine | $8,270 | -62.5% | 23 | -18 | $359 | $1,280,735 | 8 | NuMetro Distribution | false | false |
| 14 | 13 | Coraline | $7,717 | -49.2% | 9 | -1 | $857 | $191,902 | 7 | United International Pictures | false | false |
| 15 | 14 | Star Trek | $6,940 | -39.8% | 14 | -6 | $495 | $365,821 | 7 | United International Pictures | false | false |
| 16 | 15 | The Burning Plain | $6,518 | -43.4% | 10 | - | $651 | $52,209 | 3 | United International Pictures | false | false |
| 17 | 17 | The Last House on the Left | $5,032 | -32.6% | 15 | -1 | $335 | $116,829 | 5 | United International Pictures | false | false |
| 18 | 18 | Slumdog Millionaire | $3,809 | -41.4% | 15 | +1 | $253 | $1,208,976 | 16 | Ster-Kinekor Pictures | false | false |
| 19 | 12 | White Wedding | $3,487 | -77.6% | 12 | -11 | $290 | $587,344 | 8 | Ster-Kinekor Pictures | false | false |
| 20 | 16 | Adventureland | $3,057 | -72% | 1 | -9 | $3,057 | $22,712 | 2 | Ster-Kinekor Pictures | false | false |
| 21 | 20 | The Reader | $2,923 | -36% | 7 | - | $417 | $325,361 | 13 | Ster-Kinekor Pictures | false | false |
| 22 | 21 | Miss March | $1,745 | -46.8% | 4 | -1 | $436 | $19,737 | 4 | NuMetro Distribution | false | false |
| 23 | 19 | The Uninvited | $1,715 | -73.4% | 7 | -1 | $245 | $38,634 | 4 | United International Pictures | false | false |
| 24 | - | Then She Found Me | $1,024 | - | 1 | - | $1,024 | $12,613 | 16 | NuMetro Distribution | false | false |
