| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | The Hangover | $543,885 | -25.1% | 67 | +3 | $8,117 | $1,493,031 | 2 | Warner Bros. | false | false |
| 2 | - | The Proposal | $517,490 | - | 84 | - | $6,160 | $565,001 | 1 | Walt Disney Pictures | true | false |
| 3 | 2 | Angels & Demons | $350,808 | -26.1% | 125 | -4 | $2,806 | $6,741,969 | 6 | Sony Pictures Releasing | false | false |
| 4 | 3 | Terminator Salvation | $200,294 | -40.9% | 102 | -7 | $1,963 | $1,819,044 | 3 | Sony Pictures Releasing | false | false |
| 5 | 4 | Night at the Museum: Battle of the Smithsonian | $142,651 | -30.8% | 102 | +1 | $1,398 | $2,053,501 | 5 | Warner Bros. | false | false |
| 6 | - | State of Play | $112,148 | - | 47 | - | $2,386 | $144,955 | 1 | Universal Pictures International (UPI) | true | false |
| 7 | 5 | Coco Before Chanel | $61,133 | -30% | 31 | - | $1,972 | $596,342 | 4 | RCV Film Distribution | false | false |
| 8 | 7 | The Last House on the Left | $41,485 | -42.5% | 20 | - | $2,074 | $172,687 | 2 | Universal Pictures International (UPI) | false | false |
| 9 | 6 | Duplicity | $38,612 | -52.4% | 33 | -5 | $1,170 | $525,138 | 4 | Universal Pictures International (UPI) | false | false |
| 10 | 9 | Beverly Hills Chihuahua | $35,450 | -27.4% | 60 | - | $590 | $904,097 | 9 | Walt Disney Pictures | false | false |
| 11 | 8 | 17 Again | $33,327 | -44.3% | 66 | -1 | $504 | $2,217,772 | 9 | RCV Film Distribution | false | false |
| 12 | 14 | Monsters vs. Aliens | $27,204 | -15% | 95 | +6 | $286 | $2,159,673 | 12 | Universal Pictures International (UPI) | false | false |
| 13 | 11 | Star Trek | $24,731 | -41.5% | 21 | -22 | $1,177 | $1,478,724 | 7 | Universal Pictures International (UPI) | false | false |
| 14 | 13 | The Reader | $24,659 | -35.2% | 35 | - | $704 | $1,808,936 | 12 | Benelux Film Distributors | false | false |
| 15 | 15 | Disgrace | $21,705 | -26.6% | 11 | - | $1,973 | $127,927 | 3 | A-Film Distribution | false | false |
| 16 | 16 | Coraline | $18,969 | -28.3% | 64 | -5 | $296 | $324,698 | 6 | Universal Pictures International (UPI) | false | false |
| 17 | 12 | Fighting | $18,842 | -55.4% | 19 | -13 | $991 | $592,992 | 5 | Universal Pictures International (UPI) | false | false |
| 18 | 10 | I Love You, Man | $17,056 | -62.4% | 26 | -3 | $656 | $300,561 | 4 | Universal Pictures International (UPI) | false | false |
| 19 | - | The Girl on the Train | $16,765 | - | 11 | - | $1,524 | $19,186 | 1 | Benelux Film Distributors | true | false |
| 20 | 18 | Slumdog Millionaire | $15,536 | -29.4% | 36 | -4 | $431 | $5,213,919 | 19 | Cinéart | false | false |
