| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Up | $558,856 | -27.9% | 165 | +5 | $3,387 | $2,957,908 | 3 | Walt Disney Pictures | false | false |
| 2 | 2 | Terminator Salvation | $187,071 | -42.7% | 112 | -3 | $1,670 | $1,436,978 | 3 | Sony Pictures Releasing | false | false |
| 3 | 4 | Night at the Museum: Battle of the Smithsonian | $87,931 | -30% | 104 | -7 | $845 | $1,770,086 | 5 | 20th Century Fox International | false | false |
| 4 | 3 | Angels & Demons | $77,289 | -38.9% | 69 | -8 | $1,120 | $2,609,746 | 6 | Sony Pictures Releasing | false | false |
| 5 | - | 17 Again | $62,756 | - | 32 | - | $1,961 | $62,756 | 1 | Cine Colombia | true | false |
| 6 | 5 | Transporter 3 | $51,868 | -33.5% | 43 | -5 | $1,206 | $186,994 | 2 | Cineplex | false | false |
| 7 | 6 | Death Defying Acts | $35,609 | -40.7% | 36 | +4 | $989 | $137,374 | 2 | Cine Colombia | false | false |
| 8 | 8 | Duplicity | $26,162 | +21.6% | 24 | - | $1,090 | $178,752 | 4 | United International Pictures | false | false |
| 9 | 7 | The Unborn | $22,735 | -29.2% | 23 | -4 | $988 | $421,337 | 7 | United International Pictures | false | false |
| 10 | 9 | The Class | $10,232 | -25.3% | 12 | - | $852 | $33,799 | 2 | - | false | false |
| 11 | - | Summer Hours | $6,689 | - | 6 | - | $1,114 | $6,689 | 1 | Cineplex | true | false |
| 12 | 10 | X-Men Origins: Wolverine | $5,869 | -14.1% | 4 | -7 | $1,467 | $1,629,771 | 8 | 20th Century Fox International | false | false |
| 13 | 12 | Righteous Kill | $3,029 | -28.3% | 4 | -1 | $757 | $164,390 | 4 | Cine Colombia | false | false |
| 14 | 13 | Monsters vs. Aliens | $2,452 | -31.5% | 3 | -3 | $817 | $2,088,430 | 12 | United International Pictures | false | false |
| 15 | 11 | Venus 2009 Re-release | $2,060 | -67.3% | 3 | -1 | $686 | $51,785 | 5 | Cine Colombia | false | false |
| 16 | 14 | Frozen River | $1,780 | -5% | 3 | - | $593 | $27,586 | 5 | Sony Pictures Releasing | false | false |
| 17 | 18 | Earth | $1,738 | +88.9% | 7 | -9 | $248 | $240,111 | 9 | Walt Disney Pictures | false | false |
| 18 | 15 | Hannah Montana: The Movie | $1,051 | -42.8% | 8 | -4 | $131 | $542,492 | 8 | Walt Disney Pictures | false | false |
| 19 | 16 | Happy-Go-Lucky | $767 | -49% | 1 | -2 | $767 | $204,521 | 4 | Cineplex | false | false |
| 20 | 17 | Star Trek | $723 | -24.6% | 2 | -1 | $361 | $277,688 | 7 | United International Pictures | false | false |
| 21 | 19 | Race to Witch Mountain | $17 | -96.5% | 1 | -1 | $17 | $1,404,644 | 13 | Walt Disney Pictures | false | false |
