| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Transformers: Revenge of the Fallen | $998,778 | - | 92 | - | $10,856 | $1,025,208 | 1 | Universal Pictures International (UPI) | true | false |
| 2 | 1 | The Proposal | $282,676 | -38.2% | 46 | +1 | $6,145 | $992,218 | 2 | Walt Disney Pictures | false | false |
| 3 | 2 | The Hangover | $195,156 | -43.2% | 45 | - | $4,336 | $761,150 | 2 | Warner Bros. | false | false |
| 4 | - | Drag Me to Hell | $126,781 | - | 31 | - | $4,089 | $141,592 | 1 | Belga Films | true | false |
| 5 | 5 | Night at the Museum: Battle of the Smithsonian | $126,179 | -31.7% | 50 | -15 | $2,523 | $2,181,479 | 6 | 20th Century Fox International | false | false |
| 6 | 3 | Angels & Demons | $121,807 | -45.4% | 98 | - | $1,242 | $4,179,637 | 7 | Sony Pictures Releasing | false | false |
| 7 | 4 | Terminator Salvation | $88,442 | -55.2% | 77 | - | $1,148 | $1,456,714 | 4 | Sony Pictures Releasing | false | false |
| 8 | 6 | State of Play | $80,900 | -47.5% | 30 | - | $2,696 | $284,460 | 2 | Universal Pictures International (UPI) | false | false |
| 9 | - | The French Kissers | $77,823 | - | 18 | - | $4,323 | $77,823 | 1 | Alternative Films | true | false |
| 10 | 7 | Coraline | $56,205 | -49.4% | 47 | -11 | $1,195 | $364,768 | 3 | Universal Pictures International (UPI) | false | false |
| 11 | 8 | 17 Again | $25,687 | -50% | 24 | -6 | $1,070 | $1,207,200 | 8 | Kinepolis Film Distribution (KFD) | false | false |
| 12 | 10 | A Town Called Panic | $20,503 | -51.4% | 19 | - | $1,079 | $78,468 | 2 | Cinéart | false | false |
| 13 | - | Don't Look Back | $20,494 | - | 11 | - | $1,863 | $46,780 | 1 | Cinéart | true | false |
| 14 | 13 | X-Men Origins: Wolverine | $20,091 | -30.3% | 15 | -11 | $1,339 | $2,345,372 | 9 | 20th Century Fox International | false | false |
| 15 | 9 | Looking for Eric | $19,382 | -55% | 17 | -1 | $1,140 | $172,909 | 3 | Cinéart | false | false |
| 16 | 12 | Beverly Hills Chihuahua | $14,124 | -54.7% | 34 | - | $415 | $1,328,023 | 13 | Walt Disney Pictures | false | false |
| 17 | - | Make It Happen | $13,718 | - | 5 | - | $2,743 | $358,023 | 12 | Benelux Film Distributors | false | false |
| 18 | 11 | The Girl with the Dragon Tattoo | $12,027 | -67.4% | 41 | - | $293 | $539,166 | 6 | Benelux Film Distributors | false | false |
| 19 | - | Paul Blart: Mall Cop | $9,225 | - | 11 | - | $838 | $73,064 | 11 | Sony Pictures Releasing | false | false |
| 20 | 14 | Monsters vs. Aliens | $8,899 | -64.6% | 26 | -10 | $342 | $1,796,397 | 13 | Universal Pictures International (UPI) | false | false |
| 21 | 15 | My Bloody Valentine | $5,296 | -76.5% | 5 | -7 | $1,059 | $600,682 | 9 | Kinepolis Film Distribution (KFD) | false | false |
| 22 | 20 | Star Trek | $4,796 | -59.8% | 13 | -5 | $368 | $1,019,530 | 8 | Universal Pictures International (UPI) | false | false |
| 23 | 18 | Knowing | $4,763 | -71.3% | 4 | -4 | $1,190 | $2,701,971 | 13 | Belga Films | false | false |
| 24 | 16 | He's Just Not That Into You | $4,578 | -76.3% | 5 | -7 | $915 | $1,180,570 | 10 | Paradiso Entertainment | false | false |
| 25 | 27 | Coco Before Chanel | $3,686 | -22.5% | 10 | -8 | $368 | $645,833 | 10 | Kinepolis Film Distribution (KFD) | false | false |
| 26 | 19 | Sunshine Cleaning | $3,650 | -69.7% | 4 | -5 | $912 | $130,044 | 4 | A-Film Distribution | false | false |
| 27 | 21 | Sister Smile | $3,411 | -66.5% | 21 | -2 | $162 | $575,010 | 8 | Kinepolis Film Distribution (KFD) | false | false |
| 28 | 24 | Fast & Furious | $3,234 | -55.6% | 4 | -6 | $808 | $3,350,469 | 12 | Universal Pictures International (UPI) | false | false |
| 29 | 22 | The Last House on the Left | $2,798 | -68% | 3 | -4 | $932 | $396,796 | 10 | Universal Pictures International (UPI) | false | false |
| 30 | - | Let's Make Money | $2,693 | - | 3 | - | $897 | $12,588 | 1 | Cinéart | true | false |
| 31 | 23 | Slumdog Millionaire | $1,710 | -78.9% | 10 | -5 | $171 | $3,794,750 | 24 | Cinéart | false | false |
| 32 | 26 | Home | $1,635 | -66.3% | 5 | -3 | $327 | $54,899 | 4 | Belga Films | false | false |
| 33 | 30 | S&M Judge | $1,515 | -59.5% | 3 | -4 | $505 | $1,142,211 | 16 | Kinepolis Film Distribution (KFD) | false | false |
| 34 | 29 | Hotel for Dogs | $1,238 | -67.2% | 2 | - | $619 | $1,302,755 | 19 | Universal Pictures International (UPI) | false | false |
| 35 | 38 | Chéri | $718 | +366.2% | 6 | - | $119 | $264,933 | 12 | Benelux Film Distributors | false | false |
| 36 | 36 | The Reader | $263 | -37.8% | 9 | - | $29 | $884,375 | 17 | Benelux Film Distributors | false | false |
| 37 | 34 | Synecdoche, New York | $204 | -75.7% | 1 | -1 | $204 | $18,763 | 7 | Paradiso Entertainment | false | false |
