| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Up | $934,905 | -2.5% | 82 | -7 | $11,401 | $2,636,204 | 2 | Walt Disney Pictures | false | false |
| 2 | 2 | Terminator Salvation | $447,841 | -24.9% | 79 | -6 | $5,668 | $1,396,661 | 2 | Sony Pictures Releasing | false | false |
| 3 | 3 | Night at the Museum: Battle of the Smithsonian | $277,486 | -35% | 62 | -4 | $4,475 | $3,431,179 | 4 | 20th Century Fox International | false | false |
| 4 | - | The Unborn | $249,362 | - | 42 | - | $5,937 | $274,632 | 1 | United International Pictures | true | false |
| 5 | 4 | Angels & Demons | $215,382 | -30.9% | 67 | -4 | $3,214 | $3,839,865 | 5 | Sony Pictures Releasing | false | false |
| 6 | 5 | Knowing | $69,986 | -42% | 27 | -11 | $2,592 | $608,351 | 3 | N/A | false | false |
| 7 | - | Traitor | $56,029 | - | 23 | - | $2,436 | $68,341 | 1 | N/A | true | false |
| 8 | - | Swing Vote | $18,181 | - | 5 | - | $3,636 | $63,461 | 3 | N/A | false | false |
| 9 | 7 | Flawless | $16,288 | -18.7% | 6 | -1 | $2,714 | $166,043 | 3 | N/A | false | false |
| 10 | 6 | Race to Witch Mountain | $13,836 | -51% | 19 | -5 | $728 | $1,779,378 | 7 | Walt Disney Pictures | false | false |
| 11 | 8 | Paris, I Love You | $9,835 | -28.9% | 2 | -1 | $4,917 | $119,260 | 5 | N/A | false | false |
| 12 | 9 | The Accidental Husband | $9,774 | +17% | 6 | - | $1,629 | $495,489 | 5 | Walt Disney Pictures | false | false |
| 13 | - | Solstice | $7,136 | - | 3 | - | $2,378 | $206,635 | 4 | N/A | false | false |
| 14 | 10 | The Diving Bell and the Butterfly | $6,066 | -25.5% | 2 | +1 | $3,033 | $62,736 | 4 | N/A | false | false |
| 15 | 22 | Swing con son | $3,731 | +10,263.9% | 4 | +3 | $932 | $75,182 | 8 | N/A | false | false |
| 16 | 14 | Earth | $2,031 | -42.4% | 4 | -2 | $507 | $367,734 | 8 | Walt Disney Pictures | false | false |
| 17 | 12 | Coraline | $1,725 | -61.5% | 7 | -5 | $246 | $543,369 | 6 | United International Pictures | false | false |
| 18 | 17 | The Strangers | $643 | +7.3% | 2 | - | $321 | $483,809 | 8 | N/A | false | false |
| 19 | 11 | X-Men Origins: Wolverine | $625 | -90.3% | 2 | -4 | $312 | $2,521,375 | 7 | 20th Century Fox International | false | false |
| 20 | 19 | Fast & Furious | $98 | -68.9% | 1 | -2 | $98 | $4,604,144 | 11 | United International Pictures | false | false |
| 21 | 20 | He's Just Not That Into You | $77 | -67.6% | 1 | - | $77 | $513,899 | 7 | N/A | false | false |
