| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Hangover | $54,732 | - | 7 | - | $7,818 | $56,140 | 1 | - | true | false |
| 2 | 1 | Terminator Salvation | $23,128 | -69.8% | 10 | - | $2,312 | $130,694 | 2 | Sony Pictures Releasing | false | false |
| 3 | - | Drag Me to Hell | $22,505 | - | 5 | - | $4,501 | $22,505 | 1 | ACME | true | false |
| 4 | 2 | Angels & Demons | $11,388 | -30.4% | 7 | -1 | $1,626 | $275,061 | 5 | Sony Pictures Releasing | false | false |
| 5 | 3 | New in Town | $9,495 | -38.4% | 5 | - | $1,899 | $33,629 | 2 | ACME | false | false |
| 6 | 6 | Night at the Museum: Battle of the Smithsonian | $8,012 | -28.8% | 8 | - | $1,001 | $86,118 | 4 | Universal Pictures International (UPI) | false | false |
| 7 | 4 | Fighting | $6,512 | -53.6% | 7 | - | $930 | $65,385 | 3 | Universal Pictures International (UPI) | false | false |
| 8 | 5 | Ghosts of Girlfriends Past | $6,067 | -48.8% | 7 | - | $866 | $54,723 | 3 | - | false | false |
| 9 | 7 | Monsters vs. Aliens | $3,184 | -25.3% | 6 | +1 | $530 | $216,052 | 11 | Universal Pictures International (UPI) | false | false |
| 10 | - | Jonas Brothers: The 3D Concert Experience | $1,852 | - | 2 | - | $926 | $1,852 | 1 | Universal Pictures International (UPI) | true | false |
| 11 | 10 | Coraline | $1,785 | -23.1% | 2 | - | $892 | $45,635 | 6 | Universal Pictures International (UPI) | false | false |
| 12 | 16 | The Tale of Despereaux | $825 | +72.6% | 5 | -1 | $165 | $283,912 | 25 | Universal Pictures International (UPI) | false | false |
| 13 | 11 | Home | $700 | -50.8% | 1 | - | $700 | $2,973 | 2 | N/A | false | false |
| 14 | 12 | My Bloody Valentine | $643 | -51.9% | 1 | -2 | $643 | $123,605 | 8 | ACME | false | false |
| 15 | 28 | Gran Torino | $481 | +902.1% | 3 | +2 | $160 | $41,204 | 12 | - | false | false |
| 16 | - | The Boy in the Striped Pajamas | $440 | - | 1 | - | $440 | $79,868 | 24 | Universal Pictures International (UPI) | false | false |
| 17 | 15 | The Uninvited | $406 | -54.1% | 1 | -1 | $406 | $19,934 | 4 | Universal Pictures International (UPI) | false | false |
| 18 | 19 | Delta | $388 | +59.7% | 1 | - | $388 | $1,443 | 3 | N/A | false | false |
| 19 | 17 | Ice Age: The Meltdown | $374 | -13.2% | 2 | - | $187 | $673,357 | 167 | Universal Pictures International (UPI) | false | false |
| 20 | 8 | 17 Again | $327 | -88.5% | 5 | - | $65 | $132,455 | 6 | - | false | false |
| 21 | 24 | Observe and Report | $210 | +130.8% | 1 | - | $210 | $22,734 | 5 | - | false | false |
| 22 | 22 | Madagascar: Escape 2 Africa | $210 | +47.9% | 1 | - | $210 | $761,198 | 29 | Universal Pictures International (UPI) | false | false |
| 23 | - | Beverly Hills Chihuahua | $148 | - | 1 | - | $148 | $135,569 | 19 | Universal Pictures International (UPI) | false | false |
| 24 | 20 | Ratatouille | $110 | -34.1% | 1 | - | $110 | $625,820 | 96 | Universal Pictures International (UPI) | false | false |
| 25 | 30 | X-Men Origins: Wolverine | $75 | +188.5% | 3 | +2 | $25 | $62,356 | 7 | Universal Pictures International (UPI) | false | false |
| 26 | 18 | Star Trek | $74 | -75.8% | 1 | - | $74 | $25,073 | 6 | Universal Pictures International (UPI) | false | false |
| 27 | 26 | Kung Fu Panda | $71 | +6% | 1 | - | $71 | $488,266 | 54 | Universal Pictures International (UPI) | false | false |
| 28 | 14 | Race to Witch Mountain | $67 | -93% | 1 | - | $67 | $36,174 | 9 | Universal Pictures International (UPI) | false | false |
| 29 | 25 | Fast & Furious | $42 | -43.2% | 1 | - | $42 | $379,426 | 11 | Universal Pictures International (UPI) | false | false |
| 30 | 31 | Confessions of a Shopaholic | $42 | +250% | 1 | - | $42 | $82,376 | 10 | Universal Pictures International (UPI) | false | false |
| 31 | 29 | I Love You, Man | $31 | -20.5% | 1 | -1 | $31 | $37,477 | 8 | Universal Pictures International (UPI) | false | false |
| 32 | - | Newsmakers | $23 | - | 1 | - | $23 | $7,410 | 6 | N/A | false | false |
| 33 | 23 | WALL·E | $15 | -86.7% | 2 | - | $7 | $455,225 | 48 | Universal Pictures International (UPI) | false | false |
