| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Up | $76,067 | - | 8 | - | $9,508 | $76,067 | 1 | Walt Disney Pictures | true | false |
| 2 | 1 | Terminator Salvation | $50,621 | -25.1% | 11 | - | $4,601 | $145,756 | 2 | Sony Pictures Releasing | false | false |
| 3 | 2 | My Bloody Valentine | $19,441 | -4.3% | 2 | - | $9,720 | $77,027 | 14 | - | false | false |
| 4 | 3 | Night at the Museum: Battle of the Smithsonian | $16,191 | -14.6% | 6 | -3 | $2,698 | $133,535 | 4 | 20th Century Fox International | false | false |
| 5 | 4 | Angels & Demons | $15,200 | -4.6% | 7 | - | $2,171 | $208,556 | 5 | Sony Pictures Releasing | false | false |
| 6 | - | Watchmen | $8,711 | - | 6 | - | $1,451 | $8,711 | 1 | United International Pictures | true | false |
| 7 | 6 | Che: Part Two | $3,460 | -34.8% | 3 | - | $1,153 | $14,884 | 3 | N/A | false | false |
| 8 | 7 | He's Just Not That Into You | $3,197 | -16.5% | 1 | -2 | $3,197 | $15,314 | 8 | PlayArte Pictures | false | false |
| 9 | 9 | Donkey Xote | $2,730 | +205.4% | 2 | +1 | $1,365 | $20,713 | 7 | - | false | false |
| 10 | 5 | Fast & Furious | $2,633 | -53.8% | 3 | -2 | $877 | $23,965 | 11 | United International Pictures | false | false |
| 11 | 8 | X-Men Origins: Wolverine | $728 | -63.6% | 6 | -1 | $121 | $147,666 | 7 | 20th Century Fox International | false | false |
