| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Up | $754,078 | - | 165 | - | $4,570 | $754,078 | 1 | Walt Disney Pictures | true | false |
| 2 | - | Terminator Salvation | $465,714 | - | 115 | - | $4,049 | $465,714 | 1 | Sony Pictures Releasing | true | false |
| 3 | 2 | Angels & Demons | $153,069 | -50.5% | 103 | -7 | $1,486 | $2,246,772 | 4 | Sony Pictures Releasing | false | false |
| 4 | 1 | Night at the Museum: Battle of the Smithsonian | $150,305 | -59.5% | 101 | -53 | $1,488 | $1,421,277 | 3 | 20th Century Fox International | false | false |
| 5 | 3 | Righteous Kill | $29,761 | -59% | 36 | -18 | $826 | $140,305 | 2 | Cine Colombia | false | false |
| 6 | 4 | Duplicity | $24,433 | -55% | 25 | - | $977 | $103,945 | 2 | United International Pictures | false | false |
| 7 | 5 | X-Men Origins: Wolverine | $12,570 | -75.8% | 18 | -54 | $698 | $1,607,128 | 6 | 20th Century Fox International | false | false |
| 8 | 7 | The Unborn | $9,464 | -65.4% | 18 | -11 | $525 | $330,561 | 5 | United International Pictures | false | false |
| 9 | 12 | Venus 2009 Re-release | $7,511 | -10.3% | 3 | - | $2,503 | $36,247 | 3 | Cine Colombia | false | false |
| 10 | 6 | Hannah Montana: The Movie | $6,899 | -77.8% | 25 | -18 | $275 | $536,588 | 6 | Walt Disney Pictures | false | false |
| 11 | 17 | Frozen River | $4,065 | +5% | 3 | - | $1,355 | $20,884 | 3 | Sony Pictures Releasing | false | false |
| 12 | 13 | Happy-Go-Lucky | $3,589 | -51.5% | 5 | -4 | $717 | $14,631 | 2 | Cineplex | false | false |
| 13 | 14 | Earth | $2,369 | -64.1% | 17 | -2 | $139 | $233,786 | 7 | Walt Disney Pictures | false | false |
| 14 | 10 | The Strangers | $1,950 | -83.9% | 4 | -17 | $487 | $75,555 | 3 | Cine Colombia | false | false |
| 15 | 11 | Funny Games | $1,539 | -83.2% | 4 | -8 | $384 | $15,021 | 2 | Cine Colombia | false | false |
| 16 | 15 | Knowing | $1,429 | -77.3% | 3 | -1 | $476 | $673,618 | 8 | Cine Colombia | false | false |
| 17 | 9 | Star Trek | $1,356 | -88.8% | 4 | -19 | $339 | $274,911 | 5 | United International Pictures | false | false |
| 18 | 18 | Race to Witch Mountain | $981 | -39.3% | 3 | -5 | $327 | $1,403,579 | 11 | Walt Disney Pictures | false | false |
| 19 | 8 | Monsters vs. Aliens | $839 | -94.6% | 9 | -26 | $93 | $2,079,239 | 10 | United International Pictures | false | false |
| 20 | 16 | Paul Blart: Mall Cop | $555 | -85.7% | 2 | -10 | $277 | $140,216 | 5 | Sony Pictures Releasing | false | false |
