| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Fighting | $19,794 | - | 7 | - | $2,827 | $19,794 | 1 | Universal Pictures International (UPI) | true | false |
| 2 | 1 | Angels & Demons | $16,525 | -59.7% | 9 | -1 | $1,836 | $224,833 | 3 | Sony Pictures Releasing | false | false |
| 3 | - | Ghosts of Girlfriends Past | $13,685 | - | 7 | - | $1,955 | $16,354 | 1 | - | true | false |
| 4 | 2 | Night at the Museum: Battle of the Smithsonian | $12,300 | -47.1% | 8 | - | $1,537 | $47,401 | 2 | Universal Pictures International (UPI) | false | false |
| 5 | - | Dark Planet: Rebellion | $5,505 | - | 5 | - | $1,101 | $5,505 | 1 | ACME | true | false |
| 6 | 3 | 17 Again | $4,189 | -65.6% | 6 | -1 | $698 | $123,597 | 4 | - | false | false |
| 7 | 4 | The Uninvited | $3,205 | -54.6% | 3 | - | $1,068 | $14,709 | 2 | Universal Pictures International (UPI) | false | false |
| 8 | 5 | Monsters vs. Aliens | $2,958 | -51.6% | 7 | -1 | $422 | $202,502 | 9 | Universal Pictures International (UPI) | false | false |
| 9 | 7 | Coraline | $1,936 | -50% | 2 | - | $968 | $37,946 | 4 | Universal Pictures International (UPI) | false | false |
| 10 | 9 | My Bloody Valentine | $1,096 | -54.3% | 2 | -4 | $548 | $119,552 | 6 | ACME | false | false |
| 11 | 10 | Star Trek | $1,036 | -54.1% | 2 | -1 | $518 | $23,921 | 4 | Universal Pictures International (UPI) | false | false |
| 12 | 8 | X-Men Origins: Wolverine | $1,002 | -71.9% | 8 | - | $125 | $61,521 | 5 | Universal Pictures International (UPI) | false | false |
| 13 | 6 | Observe and Report | $851 | -79.6% | 4 | -1 | $212 | $21,870 | 3 | - | false | false |
| 14 | 21 | The Tale of Despereaux | $548 | +249% | 6 | +4 | $91 | $281,773 | 23 | Universal Pictures International (UPI) | false | false |
| 15 | 14 | I Love You, Man | $545 | +1.1% | 4 | +2 | $136 | $36,870 | 6 | Universal Pictures International (UPI) | false | false |
| 16 | 12 | Fast & Furious | $332 | -68.6% | 2 | -1 | $166 | $380,249 | 9 | Universal Pictures International (UPI) | false | false |
| 17 | - | Revolutionary Road | $257 | - | 1 | - | $257 | $57,055 | 18 | Universal Pictures International (UPI) | false | false |
| 18 | - | Delta | $179 | - | 1 | - | $179 | $179 | 1 | N/A | true | false |
| 19 | 27 | Kung Fu Panda | $140 | +89.2% | 1 | - | $140 | $489,808 | 52 | Universal Pictures International (UPI) | false | false |
| 20 | 24 | Ice Age: The Meltdown | $127 | +5% | 2 | - | $63 | $674,582 | 165 | Universal Pictures International (UPI) | false | false |
| 21 | - | Ratatouille | $127 | - | 1 | - | $127 | $627,821 | 94 | Universal Pictures International (UPI) | false | false |
| 22 | 20 | Madagascar: Escape 2 Africa | $90 | -45.5% | 1 | - | $90 | $763,524 | 27 | Universal Pictures International (UPI) | false | false |
| 23 | 18 | Race to Witch Mountain | $69 | -61% | 2 | - | $34 | $35,037 | 7 | Universal Pictures International (UPI) | false | false |
| 24 | 25 | WALL·E | $68 | -25.3% | 2 | - | $34 | $456,692 | 46 | Universal Pictures International (UPI) | false | false |
| 25 | 22 | Involuntary | $55 | -58.6% | 1 | - | $55 | $6,186 | 9 | N/A | false | false |
| 26 | 13 | Confessions of a Shopaholic | $39 | -93.1% | 1 | -3 | $39 | $82,574 | 8 | Universal Pictures International (UPI) | false | false |
| 27 | 28 | Gran Torino | $29 | -39.6% | 1 | -1 | $29 | $40,750 | 10 | - | false | false |
| 28 | - | Bolt | $23 | - | 1 | - | $23 | $333,244 | 14 | Universal Pictures International (UPI) | false | false |
| 29 | - | Role Models | $10 | - | 1 | - | $10 | $35,144 | 14 | Universal Pictures International (UPI) | false | false |
| 30 | 17 | The Crimson Wing: Mystery of the Flamingos | $7 | -97.4% | 1 | - | $7 | $23,956 | 12 | Universal Pictures International (UPI) | false | false |
