| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 2 | Night at the Museum: Battle of the Smithsonian | $282,581 | -43.1% | 71 | +4 | $3,980 | $829,981 | 2 | 20th Century Fox International | false | false |
| 2 | 1 | Angels & Demons | $249,430 | -50.1% | 69 | -4 | $3,614 | $1,639,023 | 3 | Sony Pictures Releasing | false | false |
| 3 | 3 | Knowing | $118,749 | -23.3% | 30 | +2 | $3,958 | $320,550 | 2 | N/A | false | false |
| 4 | 4 | Hannah Montana: The Movie | $59,352 | -52.3% | 36 | -1 | $1,648 | $971,469 | 5 | Walt Disney Pictures | false | false |
| 5 | - | Duplicity | $40,821 | - | 21 | - | $1,943 | $40,821 | 1 | United International Pictures | true | false |
| 6 | 5 | X-Men Origins: Wolverine | $29,127 | -53.5% | 26 | -12 | $1,120 | $948,521 | 5 | 20th Century Fox International | false | false |
| 7 | - | Gomorrah | $19,240 | - | 14 | - | $1,374 | $19,240 | 1 | Transeuropa | true | false |
| 8 | 8 | Earth | $18,200 | -18.7% | 12 | - | $1,516 | $345,094 | 6 | Walt Disney Pictures | false | false |
| 9 | 6 | Fast & Furious | $17,441 | -59.7% | 19 | -5 | $917 | $314,015 | 4 | United International Pictures | false | false |
| 10 | 7 | Star Trek | $15,546 | -47.4% | 12 | -4 | $1,295 | $247,840 | 4 | United International Pictures | false | false |
| 11 | 10 | Vicky Cristina Barcelona | $10,480 | -29.5% | 6 | +2 | $1,746 | $201,810 | 5 | N/A | false | false |
| 12 | 11 | Monsters vs. Aliens | $8,643 | -25% | 6 | -2 | $1,440 | $1,007,275 | 9 | United International Pictures | false | false |
| 13 | 12 | Paris | $8,482 | +4.1% | 3 | -2 | $2,827 | $59,877 | 4 | N/A | false | false |
| 14 | - | My Mom's New Boyfriend | $5,104 | - | 4 | - | $1,276 | $5,104 | 1 | Andes Films | true | false |
| 15 | 9 | Ghosts of Girlfriends Past | $4,953 | -74.6% | 4 | -9 | $1,238 | $74,508 | 3 | Warner Bros. | false | false |
| 16 | 14 | 17 Again | $441 | -64.7% | 1 | -1 | $441 | $132,839 | 6 | Warner Bros. | false | false |
| 17 | 13 | Race to Witch Mountain | $330 | -92.4% | 1 | -6 | $330 | $666,489 | 8 | Walt Disney Pictures | false | false |
