| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Night at the Museum: Battle of the Smithsonian | $251,879 | - | 80 | - | $3,148 | $251,879 | 1 | NuMetro Distribution | true | false |
| 2 | 1 | Angels & Demons | $138,898 | -48.5% | 80 | - | $1,736 | $508,893 | 2 | Ster-Kinekor Pictures | false | false |
| 3 | 2 | Ghosts of Girlfriends Past | $93,535 | -46.4% | 47 | +1 | $1,990 | $329,149 | 2 | NuMetro Distribution | false | false |
| 4 | 3 | X-Men Origins: Wolverine | $68,029 | -34.3% | 79 | -1 | $861 | $1,057,632 | 4 | NuMetro Distribution | false | false |
| 5 | 5 | White Wedding | $50,978 | -21.5% | 38 | -1 | $1,341 | $428,819 | 4 | Ster-Kinekor Pictures | false | false |
| 6 | 4 | Hannah Montana: The Movie | $48,090 | -38.7% | 66 | - | $728 | $564,067 | 4 | Ster-Kinekor Pictures | false | false |
| 7 | 7 | 17 Again | $39,175 | -21.6% | 54 | -1 | $725 | $1,032,680 | 6 | NuMetro Distribution | false | false |
| 8 | 6 | Star Trek | $36,043 | -36.3% | 36 | -7 | $1,001 | $245,756 | 3 | United International Pictures | false | false |
| 9 | - | The Last House on the Left | $26,408 | - | 25 | - | $1,056 | $26,408 | 1 | United International Pictures | true | false |
| 10 | 9 | Fast & Furious | $20,872 | -16.9% | 47 | -4 | $444 | $1,729,468 | 7 | United International Pictures | false | false |
| 11 | 8 | Coraline | $16,800 | -46.2% | 20 | -3 | $840 | $104,389 | 3 | United International Pictures | false | false |
| 12 | 10 | Slumdog Millionaire | $11,627 | -23.9% | 19 | +1 | $611 | $1,139,013 | 12 | Ster-Kinekor Pictures | false | false |
| 13 | 11 | The Unborn | $8,934 | -38.1% | 15 | - | $595 | $31,806 | 2 | United International Pictures | false | false |
| 14 | - | Blindness | $7,843 | - | 10 | - | $784 | $7,843 | 1 | Ster-Kinekor Pictures | true | false |
| 15 | 18 | The Reader | $7,554 | -7.1% | 9 | -1 | $839 | $286,720 | 9 | Ster-Kinekor Pictures | false | false |
| 16 | 12 | Hotel for Dogs | $7,349 | -43.5% | 23 | +1 | $319 | $314,598 | 6 | United International Pictures | false | false |
| 17 | 17 | The International | $7,304 | -22.3% | 10 | -4 | $730 | $194,204 | 5 | Ster-Kinekor Pictures | false | false |
| 18 | 14 | I Love You, Man | $7,188 | -35.4% | 18 | -8 | $399 | $293,781 | 5 | United International Pictures | false | false |
| 19 | 19 | Milk | $4,967 | -37.6% | 8 | -2 | $620 | $108,510 | 5 | Ster-Kinekor Pictures | false | false |
| 20 | 16 | Monsters vs. Aliens | $4,151 | -58.1% | 10 | -13 | $415 | $1,403,609 | 8 | United International Pictures | false | false |
| 21 | 13 | Street Fighter: The Legend of Chun-Li | $3,567 | -70.7% | 14 | -16 | $254 | $58,551 | 3 | NuMetro Distribution | false | false |
| 22 | 22 | Gran Torino | $2,556 | -22.6% | 8 | - | $319 | $279,254 | 9 | NuMetro Distribution | false | false |
| 23 | 21 | Marley & Me | $2,013 | -55.4% | 8 | -8 | $251 | $1,440,176 | 10 | NuMetro Distribution | false | false |
| 24 | - | Then She Found Me | $818 | - | 1 | - | $818 | $1,847 | 12 | NuMetro Distribution | false | false |
