| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Night at the Museum: Battle of the Smithsonian | $893,928 | - | 82 | - | $10,901 | $893,928 | 1 | 20th Century Fox International | true | false |
| 2 | 1 | Angels & Demons | $614,548 | -18.9% | 83 | -6 | $7,404 | $1,868,060 | 2 | Sony Pictures Releasing | false | false |
| 3 | 2 | X-Men Origins: Wolverine | $149,314 | -52.1% | 42 | -16 | $3,555 | $2,338,283 | 4 | 20th Century Fox International | false | false |
| 4 | 3 | Race to Witch Mountain | $137,978 | -49% | 39 | -1 | $3,537 | $1,489,579 | 4 | Walt Disney Pictures | false | false |
| 5 | 6 | The Accidental Husband | $83,934 | -39.3% | 26 | - | $3,228 | $335,743 | 2 | Walt Disney Pictures | false | false |
| 6 | 4 | Coraline | $74,868 | -47.9% | 29 | -8 | $2,581 | $477,869 | 3 | United International Pictures | false | false |
| 7 | - | Solstice | $61,714 | - | 15 | - | $4,114 | $61,714 | 1 | N/A | true | false |
| 8 | 5 | Star Trek | $40,310 | -71.4% | 13 | -32 | $3,100 | $513,190 | 3 | United International Pictures | false | false |
| 9 | 7 | Fast & Furious | $37,706 | -66.6% | 28 | -10 | $1,346 | $4,547,214 | 8 | United International Pictures | false | false |
| 10 | 8 | He's Just Not That Into You | $25,211 | -63.1% | 13 | -11 | $1,939 | $485,199 | 4 | N/A | false | false |
| 11 | 12 | Paris, I Love You | $16,697 | -36.3% | 3 | -2 | $5,565 | $55,184 | 2 | N/A | false | false |
| 12 | 10 | Earth | $15,356 | -49.8% | 10 | - | $1,535 | $331,170 | 5 | Walt Disney Pictures | false | false |
| 13 | - | The Diving Bell and the Butterfly | $14,705 | - | 3 | - | $4,901 | $24,614 | 1 | N/A | true | false |
| 14 | 9 | The Strangers | $11,285 | -65.1% | 8 | -3 | $1,410 | $462,394 | 5 | N/A | false | false |
| 15 | 11 | Monsters vs. Aliens | $7,346 | -72% | 13 | -24 | $565 | $3,025,425 | 8 | United International Pictures | false | false |
| 16 | 14 | Inkheart | $6,983 | -58.1% | 12 | -6 | $581 | $946,191 | 9 | N/A | false | false |
| 17 | 15 | Balls of Fury | $5,837 | -60.9% | 7 | -1 | $833 | $232,862 | 6 | N/A | false | false |
| 18 | 18 | Swing con son | $4,271 | -21.7% | 4 | -2 | $1,067 | $65,433 | 5 | N/A | false | false |
| 19 | 13 | Catacombs | $4,196 | -76.5% | 4 | -9 | $1,049 | $204,775 | 5 | N/A | false | false |
| 20 | 16 | Slumdog Millionaire | $2,025 | -85.5% | 5 | -8 | $405 | $1,736,419 | 13 | N/A | false | false |
| 21 | 23 | Underworld: Rise of the Lycans | $1,858 | +5.7% | 2 | - | $929 | $1,031,740 | 9 | Sony Pictures Releasing | false | false |
| 22 | 19 | Milk | $1,743 | -44.9% | 4 | -5 | $435 | $62,943 | 3 | United International Pictures | false | false |
| 23 | 17 | Sex Drive | $597 | -93.4% | 2 | -3 | $298 | $208,669 | 6 | N/A | false | false |
