| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Angels & Demons | $40,976 | -38.1% | 10 | - | $4,097 | $189,526 | 2 | Sony Pictures Releasing | false | false |
| 2 | - | Night at the Museum: Battle of the Smithsonian | $23,236 | - | 8 | - | $2,904 | $23,236 | 1 | Universal Pictures International (UPI) | true | false |
| 3 | 2 | 17 Again | $12,185 | -19.5% | 7 | - | $1,740 | $113,324 | 3 | - | false | false |
| 4 | - | The Uninvited | $7,061 | - | 3 | - | $2,353 | $7,390 | 1 | Universal Pictures International (UPI) | true | false |
| 5 | 3 | Monsters vs. Aliens | $6,117 | -16.6% | 8 | -1 | $764 | $194,762 | 8 | Universal Pictures International (UPI) | false | false |
| 6 | 5 | Observe and Report | $4,179 | -34.4% | 5 | - | $835 | $18,728 | 2 | - | false | false |
| 7 | 4 | Coraline | $3,870 | -41.3% | 2 | - | $1,935 | $33,787 | 3 | Universal Pictures International (UPI) | false | false |
| 8 | 6 | X-Men Origins: Wolverine | $3,560 | -35.5% | 8 | - | $445 | $58,575 | 4 | Universal Pictures International (UPI) | false | false |
| 9 | 10 | My Bloody Valentine | $2,399 | +66.7% | 6 | - | $399 | $115,976 | 5 | ACME | false | false |
| 10 | 7 | Star Trek | $2,255 | -37.3% | 3 | - | $751 | $21,584 | 3 | Universal Pictures International (UPI) | false | false |
| 11 | 12 | Knowing | $2,165 | +134.1% | 1 | - | $2,165 | $81,859 | 7 | ACME | false | false |
| 12 | 8 | Fast & Furious | $1,058 | -49.1% | 3 | -3 | $352 | $376,561 | 8 | Universal Pictures International (UPI) | false | false |
| 13 | 15 | Confessions of a Shopaholic | $564 | -15.4% | 4 | - | $141 | $81,422 | 7 | Universal Pictures International (UPI) | false | false |
| 14 | 9 | I Love You, Man | $539 | -66.1% | 2 | -3 | $269 | $34,417 | 5 | Universal Pictures International (UPI) | false | false |
| 15 | 11 | Newsmakers | $357 | -70.5% | 3 | - | $119 | $7,118 | 3 | N/A | false | false |
| 16 | - | Push | $285 | - | 1 | - | $285 | $6,179 | 1 | ACME | true | false |
| 17 | 23 | The Crimson Wing: Mystery of the Flamingos | $269 | +449% | 1 | - | $269 | $23,723 | 11 | Universal Pictures International (UPI) | false | false |
| 18 | 21 | Race to Witch Mountain | $177 | -11.9% | 2 | +1 | $88 | $34,647 | 6 | Universal Pictures International (UPI) | false | false |
| 19 | 14 | Taken | $172 | -79% | 1 | -5 | $172 | $33,413 | 5 | ACME | false | false |
| 20 | - | Madagascar: Escape 2 Africa | $165 | - | 1 | - | $165 | $757,765 | 26 | Universal Pictures International (UPI) | false | false |
| 21 | - | The Tale of Despereaux | $157 | - | 2 | - | $78 | $279,069 | 22 | Universal Pictures International (UPI) | false | false |
| 22 | 24 | Involuntary | $133 | +202.3% | 1 | - | $133 | $5,900 | 8 | N/A | false | false |
| 23 | 17 | The Class | $131 | -58.4% | 2 | - | $65 | $23,770 | 6 | N/A | false | false |
| 24 | - | Ice Age: The Meltdown | $121 | - | 2 | - | $60 | $669,237 | 164 | Universal Pictures International (UPI) | false | false |
| 25 | - | WALL·E | $91 | - | 2 | - | $45 | $452,944 | 45 | Universal Pictures International (UPI) | false | false |
| 26 | 26 | Duplicity | $81 | +478.6% | 2 | +1 | $40 | $51,258 | 10 | Universal Pictures International (UPI) | false | false |
| 27 | - | Kung Fu Panda | $74 | - | 1 | - | $74 | $486,026 | 51 | Universal Pictures International (UPI) | false | false |
| 28 | 22 | Gran Torino | $48 | -47.8% | 2 | -1 | $24 | $40,396 | 9 | - | false | false |
| 29 | 25 | Hotel for Dogs | $29 | -25.6% | 1 | - | $29 | $50,128 | 10 | Universal Pictures International (UPI) | false | false |
| 30 | 18 | Marley & Me | $13 | -95.8% | 1 | - | $13 | $140,353 | 11 | Universal Pictures International (UPI) | false | false |
