| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Angels & Demons | $44,246 | +14.2% | 6 | - | $7,374 | $134,717 | 2 | Sony Pictures Releasing | false | false |
| 2 | - | Night at the Museum: Battle of the Smithsonian | $21,246 | - | 6 | - | $3,541 | $29,679 | 1 | 20th Century Fox International | true | false |
| 3 | - | The Last House on the Left | $10,132 | - | 3 | - | $3,377 | $16,353 | 1 | N/A | true | false |
| 4 | 2 | Star Trek | $7,383 | -39.4% | 5 | - | $1,476 | $83,404 | 3 | United International Pictures | false | false |
| 5 | 3 | Hannah Montana: The Movie | $5,925 | -20.3% | 4 | - | $1,481 | $15,973 | 2 | Walt Disney Pictures | false | false |
| 6 | 4 | X-Men Origins: Wolverine | $5,188 | +48.2% | 4 | -3 | $1,297 | $112,363 | 4 | 20th Century Fox International | false | false |
| 7 | 7 | The True Story of Puss'N Boots | $4,517 | +215.4% | 4 | - | $1,129 | $28,548 | 4 | N/A | false | false |
| 8 | 6 | 17 Again | $2,195 | +26.3% | 2 | -1 | $1,097 | $107,579 | 6 | N/A | false | false |
| 9 | 10 | Monsters vs. Aliens | $2,042 | +220.1% | 5 | -3 | $408 | $149,380 | 8 | United International Pictures | false | false |
| 10 | 9 | Dreamland | $1,988 | +120.4% | 2 | - | $994 | $113,253 | 7 | N/A | false | false |
| 11 | 5 | The Boat That Rocked | $1,499 | -27.9% | 2 | -1 | $749 | $19,551 | 3 | United International Pictures | false | false |
| 12 | 8 | Observe and Report | $1,232 | +28.9% | 1 | - | $1,232 | $45,339 | 5 | N/A | false | false |
| 13 | 12 | I Love You, Man | $1,206 | +116.9% | 2 | - | $603 | $106,035 | 7 | United International Pictures | false | false |
| 14 | 11 | New in Town | $869 | +51.4% | 2 | - | $434 | $21,540 | 4 | N/A | false | false |
| 15 | 17 | The Unborn | $534 | +295.6% | 2 | - | $267 | $18,277 | 9 | United International Pictures | false | false |
| 16 | 14 | Let the Right One In | $443 | +15.7% | 1 | - | $443 | $13,743 | 6 | N/A | false | false |
| 17 | 15 | Crank: High Voltage | $309 | +39.8% | 1 | - | $309 | $44,498 | 5 | N/A | false | false |
