| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Angels & Demons | $757,952 | - | 89 | - | $8,516 | $757,952 | 1 | Sony Pictures Releasing | true | false |
| 2 | 1 | X-Men Origins: Wolverine | $311,954 | -7.8% | 58 | -2 | $5,378 | $2,043,983 | 3 | 20th Century Fox International | false | false |
| 3 | 2 | Race to Witch Mountain | $270,312 | +18.8% | 40 | - | $6,757 | $1,257,383 | 3 | Walt Disney Pictures | false | false |
| 4 | 5 | Coraline | $143,670 | +6.8% | 37 | - | $3,882 | $350,511 | 2 | United International Pictures | false | false |
| 5 | 3 | Star Trek | $141,040 | -14.9% | 45 | - | $3,134 | $404,825 | 2 | United International Pictures | false | false |
| 6 | - | The Accidental Husband | $138,277 | - | 26 | - | $5,318 | $172,085 | 1 | Walt Disney Pictures | true | false |
| 7 | 4 | Fast & Furious | $112,762 | -16.5% | 38 | -11 | $2,967 | $4,448,875 | 7 | United International Pictures | false | false |
| 8 | 6 | He's Just Not That Into You | $68,322 | -9.3% | 24 | -1 | $2,846 | $416,414 | 3 | N/A | false | false |
| 9 | 7 | The Strangers | $32,334 | -22.8% | 11 | -3 | $2,939 | $434,085 | 4 | N/A | false | false |
| 10 | 8 | Earth | $30,611 | -20.8% | 10 | - | $3,061 | $306,666 | 4 | Walt Disney Pictures | false | false |
| 11 | 9 | Monsters vs. Aliens | $26,273 | -28.2% | 37 | -11 | $710 | $3,009,986 | 7 | United International Pictures | false | false |
| 12 | - | Paris, I Love You | $26,206 | - | 5 | - | $5,241 | $26,206 | 1 | N/A | true | false |
| 13 | 15 | Catacombs | $17,841 | +37.2% | 13 | +2 | $1,372 | $189,297 | 4 | N/A | false | false |
| 14 | 12 | Inkheart | $16,680 | -6% | 18 | - | $926 | $934,761 | 8 | N/A | false | false |
| 15 | 16 | Balls of Fury | $14,941 | +22.7% | 8 | - | $1,867 | $220,463 | 5 | N/A | false | false |
| 16 | 11 | Slumdog Millionaire | $13,925 | -42.9% | 13 | -3 | $1,071 | $1,725,812 | 12 | N/A | false | false |
| 17 | 23 | Sex Drive | $9,081 | +443.1% | 5 | - | $1,816 | $200,966 | 5 | N/A | false | false |
| 18 | 17 | Swing con son | $5,452 | -34% | 6 | -3 | $908 | $57,665 | 4 | N/A | false | false |
| 19 | 10 | Milk | $3,164 | -88.3% | 9 | -9 | $351 | $60,042 | 2 | United International Pictures | false | false |
| 20 | 13 | Role Models | $2,355 | -84.7% | 6 | -6 | $392 | $277,708 | 4 | United International Pictures | false | false |
| 21 | 14 | Paul Blart: Mall Cop | $2,191 | -83.9% | 2 | -7 | $1,095 | $1,305,828 | 10 | Sony Pictures Releasing | false | false |
| 22 | 22 | Confessions of a Shopaholic | $2,135 | -6.9% | 3 | -3 | $711 | $962,748 | 8 | Walt Disney Pictures | false | false |
| 23 | 19 | Underworld: Rise of the Lycans | $1,757 | -61.3% | 2 | -5 | $878 | $1,028,727 | 8 | Sony Pictures Releasing | false | false |
| 24 | 20 | Dragonball Evolution | $1,410 | -66.5% | 5 | -10 | $282 | $1,143,339 | 6 | 20th Century Fox International | false | false |
| 25 | 18 | Pride and Glory | $1,131 | -76% | 3 | -4 | $377 | $162,496 | 5 | N/A | false | false |
| 26 | 25 | The International | $258 | +94% | 1 | - | $258 | $573,995 | 11 | Sony Pictures Releasing | false | false |
