| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Angels & Demons | $1,480,809 | - | 132 | - | $11,218 | $1,710,013 | 1 | Sony Pictures Releasing | true | false |
| 2 | 1 | Star Trek | $257,961 | -37.1% | 76 | - | $3,394 | $800,299 | 2 | Universal Pictures International (UPI) | false | false |
| 3 | 2 | X-Men Origins: Wolverine | $223,373 | -40.4% | 102 | -1 | $2,189 | $2,163,364 | 3 | Warner Bros. | false | false |
| 4 | 3 | 17 Again | $180,977 | -11.9% | 70 | - | $2,585 | $1,599,844 | 4 | RCV Film Distribution | false | false |
| 5 | 4 | He's Just Not That Into You | $96,393 | -34.8% | 78 | -7 | $1,235 | $1,489,553 | 5 | Paradiso Entertainment | false | false |
| 6 | - | Coraline | $84,833 | - | 89 | - | $953 | $93,928 | 1 | Universal Pictures International (UPI) | true | false |
| 7 | 7 | The Reader | $80,063 | -18.6% | 35 | - | $2,287 | $1,420,229 | 7 | Benelux Film Distributors | false | false |
| 8 | 5 | Knowing | $72,388 | -34.9% | 58 | - | $1,248 | $1,398,191 | 6 | Independent Films | false | false |
| 9 | 6 | Monsters vs. Aliens | $70,768 | -30.4% | 114 | -5 | $620 | $1,869,185 | 7 | Universal Pictures International (UPI) | false | false |
| 10 | - | Sunshine Cleaning | $69,358 | - | 25 | - | $2,774 | $102,362 | 1 | A-Film Distribution | true | false |
| 11 | 9 | Beverly Hills Chihuahua | $65,235 | -19.3% | 60 | +1 | $1,087 | $626,795 | 4 | Walt Disney Pictures | false | false |
| 12 | 10 | Slumdog Millionaire | $63,038 | -12% | 48 | - | $1,313 | $4,792,664 | 14 | Cinéart | false | false |
| 13 | 11 | The Last Days of Emma Blank | $51,748 | -14.2% | 22 | - | $2,352 | $137,332 | 2 | A-Film Distribution | false | false |
| 14 | 12 | The Haunting in Connecticut | $33,383 | -43% | 19 | -3 | $1,757 | $235,080 | 3 | Benelux Film Distributors | false | false |
| 15 | 13 | Lemo | $31,592 | -30.1% | 97 | -8 | $325 | $599,885 | 6 | Independent Films | false | false |
| 16 | 8 | Fast & Furious | $28,942 | -66.4% | 48 | -45 | $602 | $3,559,229 | 7 | Universal Pictures International (UPI) | false | false |
| 17 | - | Eden Lake | $27,663 | - | 7 | - | $3,951 | $46,146 | 1 | Benelux Film Distributors | true | false |
| 18 | - | The Burning Plain | $15,445 | - | 9 | - | $1,716 | $22,966 | 1 | Cinéart | true | false |
| 19 | 16 | Hotel for Dogs | $12,659 | -35.1% | 36 | -1 | $351 | $1,186,296 | 13 | Universal Pictures International (UPI) | false | false |
| 20 | 14 | Street Fighter: The Legend of Chun-Li | $12,616 | -63.5% | 15 | - | $841 | $86,670 | 2 | Independent Films | false | false |
