| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Angels & Demons | $874,787 | -25.2% | 98 | - | $8,926 | $2,242,122 | 2 | Sony Pictures Releasing | false | false |
| 2 | - | Night at the Museum: Battle of the Smithsonian | $651,178 | - | 85 | - | $7,660 | $651,178 | 1 | 20th Century Fox International | true | false |
| 3 | 3 | 17 Again | $191,220 | -9.5% | 36 | - | $5,311 | $720,398 | 3 | Kinepolis Film Distribution (KFD) | false | false |
| 4 | 2 | X-Men Origins: Wolverine | $191,124 | -23.8% | 100 | - | $1,911 | $1,912,918 | 4 | 20th Century Fox International | false | false |
| 5 | 4 | Star Trek | $137,569 | -31.4% | 42 | -1 | $3,275 | $729,957 | 3 | Universal Pictures International (UPI) | false | false |
| 6 | - | The Girl with the Dragon Tattoo | $115,256 | - | 42 | - | $2,744 | $145,956 | 1 | Benelux Film Distributors | true | false |
| 7 | 8 | My Bloody Valentine | $72,532 | +0.9% | 15 | - | $4,835 | $413,738 | 4 | Kinepolis Film Distribution (KFD) | false | false |
| 8 | 7 | He's Just Not That Into You | $66,958 | -16.8% | 24 | -5 | $2,789 | $941,075 | 5 | Paradiso Entertainment | false | false |
| 9 | 5 | Sister Smile | $61,274 | -42.2% | 33 | - | $1,856 | $403,507 | 3 | Kinepolis Film Distribution (KFD) | false | false |
| 10 | 6 | Fast & Furious | $51,522 | -36.8% | 40 | -6 | $1,288 | $3,141,415 | 7 | Universal Pictures International (UPI) | false | false |
| 11 | 12 | Knowing | $41,455 | -30% | 17 | -16 | $2,438 | $2,475,498 | 8 | Belga Films | false | false |
| 12 | 10 | Monsters vs. Aliens | $39,773 | -38.2% | 63 | -6 | $631 | $1,585,867 | 8 | Universal Pictures International (UPI) | false | false |
| 13 | 9 | Beverly Hills Chihuahua | $39,402 | -42.3% | 36 | -8 | $1,094 | $1,106,010 | 8 | Walt Disney Pictures | false | false |
| 14 | 11 | Coco Before Chanel | $34,374 | -43.7% | 29 | -2 | $1,185 | $539,345 | 5 | Kinepolis Film Distribution (KFD) | false | false |
| 15 | 13 | Incognito | $28,186 | -39.2% | 14 | - | $2,013 | $252,868 | 4 | Alternative Films | false | false |
| 16 | 16 | Slumdog Millionaire | $22,478 | -32.2% | 25 | -7 | $899 | $3,575,076 | 19 | Cinéart | false | false |
| 17 | 14 | OSS 117: Lost in Rio | $20,716 | -52.8% | 13 | -7 | $1,593 | $711,075 | 6 | Belga Films | false | false |
| 18 | 17 | The Last House on the Left | $20,304 | -26.3% | 15 | -2 | $1,353 | $315,115 | 5 | Universal Pictures International (UPI) | false | false |
| 19 | 15 | Je l'aimais | $15,733 | -56.2% | 11 | - | $1,430 | $109,314 | 3 | N/A | false | false |
| 20 | 20 | S&M Judge | $10,655 | -34.9% | 12 | -2 | $887 | $1,062,184 | 11 | Kinepolis Film Distribution (KFD) | false | false |
| 21 | 19 | The Boy in the Striped Pajamas | $10,347 | -42.2% | 11 | - | $940 | $105,050 | 4 | Walt Disney Pictures | false | false |
| 22 | 18 | In the Electric Mist | $10,172 | -46.7% | 13 | - | $782 | $218,577 | 5 | Benelux Film Distributors | false | false |
| 23 | 24 | The Boat That Rocked | $5,525 | -43.2% | 12 | -5 | $460 | $71,760 | 3 | Universal Pictures International (UPI) | false | false |
| 24 | 29 | The Reader | $4,911 | -29.7% | 13 | - | $377 | $834,016 | 12 | Benelux Film Distributors | false | false |
| 25 | 22 | London River | $4,744 | -52.9% | 10 | -1 | $474 | $63,246 | 4 | ABC Distribution | false | false |
| 26 | - | Tokyo Sonata | $4,425 | - | 2 | - | $2,212 | $6,948 | 1 | A-Film Distribution | true | false |
| 27 | 30 | Ponyo | $4,261 | -39% | 8 | -1 | $532 | $96,784 | 7 | Cinéart | false | false |
| 28 | 26 | Jonas Brothers: The 3D Concert Experience | $3,622 | -55% | 9 | -3 | $402 | $11,926 | 2 | Walt Disney Pictures | false | false |
| 29 | 37 | Hotel for Dogs | $3,520 | +2.4% | 10 | -3 | $352 | $1,239,428 | 14 | Universal Pictures International (UPI) | false | false |
| 30 | 25 | Gran Torino | $3,505 | -63.8% | 5 | -5 | $701 | $1,123,285 | 13 | Warner Bros. | false | false |
| 31 | 31 | Make It Happen | $3,251 | -51.6% | 15 | - | $216 | $328,059 | 7 | Benelux Film Distributors | false | false |
| 32 | 28 | Duplicity | $3,053 | -59% | 2 | -3 | $1,526 | $910,726 | 9 | Universal Pictures International (UPI) | false | false |
| 33 | 23 | Bolt | $2,739 | -72.1% | 2 | -10 | $1,369 | $3,147,164 | 15 | Walt Disney Pictures | false | false |
| 34 | 34 | Synecdoche, New York | $2,708 | -50% | 4 | - | $677 | $10,740 | 2 | Paradiso Entertainment | false | false |
| 35 | 21 | Observe and Report | $2,514 | -80.8% | 5 | -1 | $502 | $18,243 | 2 | 20th Century Fox International | false | false |
| 36 | 36 | Katanga Business | $2,221 | -43.1% | 7 | - | $317 | $99,263 | 8 | Cinéart | false | false |
| 37 | 43 | Confessions of a Shopaholic | $2,084 | +15.3% | 1 | -1 | $2,084 | $926,725 | 10 | Walt Disney Pictures | false | false |
| 38 | 33 | The Chaser | $1,868 | -70.3% | 4 | -1 | $467 | $29,740 | 3 | Cinéart | false | false |
| 39 | 35 | Chéri | $1,205 | -77.6% | 10 | - | $120 | $242,917 | 7 | Benelux Film Distributors | false | false |
| 40 | 27 | Romaine 30° Below | $824 | -89.5% | 1 | -2 | $824 | $9,147 | 2 | Les Films de l'Elysée | false | false |
| 41 | - | The Visitor | $798 | - | 1 | - | $798 | $798 | 1 | N/A | true | false |
| 42 | 32 | Safari | $641 | -90.2% | 4 | -6 | $160 | $536,468 | 8 | Alternative Films | false | false |
| 43 | 50 | Twilight | $435 | -14.4% | 1 | - | $435 | $3,446,186 | 26 | Belga Films | false | false |
