| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | 17 Again | $307,757 | - | 70 | - | $4,396 | $307,757 | 1 | RCV Film Distribution | true | false |
| 2 | 1 | Fast & Furious | $250,445 | -18.8% | 98 | - | $2,555 | $3,002,063 | 4 | Universal Pictures International (UPI) | false | false |
| 3 | 2 | He's Just Not That Into You | $232,903 | -15.9% | 86 | +1 | $2,708 | $598,410 | 2 | Paradiso Entertainment | false | false |
| 4 | 3 | Knowing | $176,683 | -4.4% | 57 | - | $3,099 | $874,096 | 3 | Independent Films | false | false |
| 5 | 4 | The Reader | $129,248 | -10.2% | 35 | - | $3,692 | $935,509 | 4 | Benelux Film Distributors | false | false |
| 6 | 5 | Monsters vs. Aliens | $112,266 | -2.6% | 122 | -47 | $920 | $1,053,182 | 4 | Universal Pictures International (UPI) | false | false |
| 7 | 6 | The International | $86,529 | -17.1% | 40 | - | $2,163 | $285,957 | 2 | Sony Pictures Releasing | false | false |
| 8 | 7 | Slumdog Millionaire | $81,722 | -8.8% | 46 | - | $1,776 | $4,361,981 | 11 | Cinéart | false | false |
| 9 | - | Beverly Hills Chihuahua | $49,915 | - | 58 | - | $860 | $61,311 | 1 | Walt Disney Pictures | true | false |
| 10 | 10 | The Uninvited | $48,934 | -21.6% | 33 | +1 | $1,482 | $146,159 | 2 | Universal Pictures International (UPI) | false | false |
| 11 | 8 | Bride Wars | $47,084 | -42.6% | 72 | -10 | $653 | $1,362,371 | 5 | Warner Bros. | false | false |
| 12 | 12 | Lemo | $41,641 | +4% | 106 | - | $392 | $244,284 | 3 | Independent Films | false | false |
| 13 | 9 | The Boat That Rocked | $36,374 | -47.2% | 71 | -8 | $512 | $128,741 | 2 | Universal Pictures International (UPI) | false | false |
| 14 | 11 | Dragonball Evolution | $34,205 | -34.2% | 60 | - | $570 | $342,922 | 3 | Warner Bros. | false | false |
| 15 | 14 | My Bloody Valentine | $33,064 | +1.5% | 19 | -4 | $1,740 | $1,077,758 | 7 | RCV Film Distribution | false | false |
| 16 | - | Donkey Punch | $32,154 | - | 17 | - | $1,891 | $56,166 | 1 | - | true | false |
| 17 | 13 | Confessions of a Shopaholic | $23,522 | -35.4% | 38 | -14 | $619 | $1,866,412 | 7 | Walt Disney Pictures | false | false |
| 18 | 15 | Inkheart | $23,398 | -3.2% | 38 | - | $615 | $55,357 | 2 | Paradiso Entertainment | false | false |
| 19 | - | Mammoth | $20,079 | - | 16 | - | $1,254 | $26,121 | 1 | A-Film Distribution | true | false |
| 20 | 19 | My Dad's a Detective | $12,925 | +8.2% | 43 | +41 | $300 | $71,095 | 3 | RCV Film Distribution | false | false |
| 21 | - | Milk | $3,892 | - | 19 | - | $204 | $554,412 | 14 | A-Film Distribution | false | false |
| 22 | 21 | Rachel Getting Married | $519 | -46% | 2 | - | $259 | $33,901 | 9 | Sony Pictures Releasing | false | false |
