| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 3 | Race to Witch Mountain | $124,997 | -31.2% | 36 | - | $3,472 | $330,885 | 2 | Walt Disney Pictures | false | false |
| 2 | 1 | Monsters vs. Aliens | $124,579 | -38.1% | 61 | -10 | $2,042 | $683,870 | 3 | United International Pictures | false | false |
| 3 | - | The Unborn | $75,963 | - | 27 | - | $2,813 | $75,963 | 1 | United International Pictures | true | false |
| 4 | 2 | Dragonball Evolution | $68,198 | -64.1% | 54 | -3 | $1,262 | $293,056 | 2 | 20th Century Fox International | false | false |
| 5 | 5 | Gran Torino | $26,488 | -30% | 11 | +1 | $2,408 | $262,178 | 5 | Warner Bros. | false | false |
| 6 | 6 | Slumdog Millionaire | $24,611 | -26.2% | 17 | +2 | $1,447 | $696,429 | 9 | Bazuca Films | false | false |
| 7 | - | Death Sentence | $19,815 | - | 14 | - | $1,415 | $19,815 | 1 | N/A | true | false |
| 8 | 4 | Underworld: Rise of the Lycans | $16,947 | -57.6% | 27 | -3 | $627 | $302,351 | 5 | Sony Pictures Releasing | false | false |
| 9 | 8 | Changeling | $11,781 | -33.1% | 10 | -5 | $1,178 | $248,016 | 6 | United International Pictures | false | false |
| 10 | 7 | Bedtime Stories | $8,952 | -62.3% | 20 | -10 | $447 | $1,019,579 | 9 | Walt Disney Pictures | false | false |
| 11 | 9 | Confessions of a Shopaholic | $8,554 | -46.4% | 8 | -6 | $1,069 | $97,618 | 4 | Walt Disney Pictures | false | false |
| 12 | 12 | He's Just Not That Into You | $7,775 | +0.4% | 3 | - | $2,591 | $273,596 | 10 | Warner Bros. | false | false |
| 13 | 10 | Reincarnation 2009 Re-release | $5,118 | -65.7% | 6 | -1 | $853 | $62,341 | 4 | Andes Films | false | false |
| 14 | 11 | Sex Drive | $4,807 | -66.2% | 13 | +2 | $369 | $22,704 | 2 | N/A | false | false |
| 15 | 13 | Milk | $4,537 | -32.8% | 4 | - | $1,134 | $38,490 | 4 | United International Pictures | false | false |
| 16 | - | Alpha Dog | $4,110 | - | 5 | - | $822 | $4,110 | 1 | Andes Films | true | false |
| 17 | 16 | My Brother is an Only Child | $3,506 | +16.3% | 1 | - | $3,506 | $7,201 | 2 | Transeuropa | false | false |
| 18 | 14 | Doubt | $2,346 | -62.8% | 2 | -4 | $1,173 | $130,110 | 8 | Walt Disney Pictures | false | false |
| 19 | 20 | The Duchess | $1,353 | -6.4% | 1 | - | $1,353 | $75,042 | 9 | United International Pictures | false | false |
| 20 | 15 | Friday the 13th | $1,121 | -66.4% | 2 | -3 | $560 | $270,539 | 10 | United International Pictures | false | false |
| 21 | 17 | Valkyrie | $988 | -53.5% | 2 | -1 | $494 | $788,128 | 10 | 20th Century Fox International | false | false |
| 22 | 22 | Descendents | $945 | -4.5% | 4 | - | $236 | $30,775 | 5 | N/A | false | false |
| 23 | 18 | The Curious Case of Benjamin Button | $647 | -59.4% | 2 | -1 | $323 | $1,109,721 | 13 | Warner Bros. | false | false |
