| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Fast & Furious | $1,942,723 | -45.2% | 654 | - | $2,970 | $8,200,630 | 2 | Universal Pictures International (UPI) | false | false |
| 2 | 2 | Monsters vs. Aliens | $1,525,895 | -25.6% | 753 | - | $2,026 | $6,542,065 | 2 | Paramount Pictures International | false | false |
| 3 | - | Dragonball Evolution | $784,219 | - | 402 | - | $1,950 | $1,019,078 | 1 | 20th Century Fox International | true | false |
| 4 | - | Amar a morir | $446,023 | - | 322 | - | $1,385 | $550,962 | 1 | Gussi Films | true | false |
| 5 | - | Duplicity | $437,680 | - | 258 | - | $1,696 | $550,331 | 1 | Universal Pictures International (UPI) | true | false |
| 6 | 3 | Another Egg and Chicken Movie | $429,944 | -40.7% | 422 | -24 | $1,018 | $7,383,259 | 4 | Videocine | false | false |
| 7 | 4 | Knowing | $386,215 | -25.9% | 276 | -40 | $1,399 | $2,724,077 | 3 | Corazón Films | false | false |
| 8 | 5 | Race to Witch Mountain | $344,002 | -18.2% | 248 | +5 | $1,387 | $2,250,544 | 3 | Walt Disney Pictures | false | false |
| 9 | 7 | Gran Torino | $139,284 | -35.6% | 109 | -74 | $1,277 | $1,084,450 | 3 | Warner Bros. | false | false |
| 10 | 6 | The Accidental Husband | $131,142 | -53.4% | 182 | -68 | $720 | $671,283 | 2 | Walt Disney Pictures | false | false |
| 11 | 10 | Slumdog Millionaire | $117,454 | -24% | 91 | -40 | $1,290 | $5,246,341 | 8 | Gussi Films | false | false |
| 12 | 8 | The Reader | $113,974 | -36.1% | 84 | -15 | $1,356 | $458,392 | 2 | Gussi Films | false | false |
| 13 | 13 | Paul Blart: Mall Cop | $98,938 | +59.2% | 108 | -2 | $916 | $1,925,594 | 5 | Sony Pictures Releasing | false | false |
| 14 | 17 | The International | $78,192 | +215.7% | 89 | +58 | $878 | $582,920 | 4 | Sony Pictures Releasing | false | false |
| 15 | 9 | The Unborn | $54,083 | -69.3% | 88 | -139 | $614 | $4,685,471 | 5 | Universal Pictures International (UPI) | false | false |
| 16 | - | Borderland | $50,247 | - | 79 | - | $636 | $66,261 | 1 | Videocine | true | false |
| 17 | 12 | Changeling | $50,009 | -39.5% | 59 | -35 | $847 | $1,806,222 | 7 | Universal Pictures International (UPI) | false | false |
| 18 | 11 | He's Just Not That Into You | $34,174 | -61.2% | 37 | -72 | $923 | $1,843,040 | 6 | Gussi Films | false | false |
| 19 | 22 | The Wrestler | $29,722 | +151.9% | 48 | +25 | $619 | $508,130 | 7 | Corazón Films | false | false |
| 20 | 15 | Transporter 3 | $22,556 | -10.5% | 31 | -13 | $727 | $586,311 | 8 | Zima Entertainment | false | false |
| 21 | 14 | Milk | $16,974 | -58.8% | 28 | -28 | $606 | $520,437 | 6 | Universal Pictures International (UPI) | false | false |
| 22 | 16 | Doubt | $14,036 | -44% | 18 | -16 | $779 | $805,095 | 8 | Walt Disney Pictures | false | false |
| 23 | 28 | My Sassy Girl | $10,386 | +74.3% | 14 | -6 | $741 | $401,116 | 7 | Videocine | false | false |
| 24 | 24 | Rachel Getting Married | $9,071 | +12.9% | 7 | -1 | $1,295 | $74,980 | 4 | Sony Pictures Releasing | false | false |
| 25 | 29 | In Bruges | $4,300 | -16.7% | 7 | -7 | $614 | $72,750 | 4 | Corazón Films | false | false |
| 26 | 23 | The Pink Panther 2 | $3,580 | -68.9% | 21 | -23 | $170 | $2,165,781 | 7 | Sony Pictures Releasing | false | false |
| 27 | 19 | Underworld: Rise of the Lycans | $3,008 | -82.5% | 8 | -31 | $376 | $3,827,532 | 10 | Sony Pictures Releasing | false | false |
| 28 | 30 | The Spirit | $2,839 | -42.6% | 9 | -7 | $315 | $461,286 | 12 | Sony Pictures Releasing | false | false |
| 29 | 38 | Fierce People | $2,580 | +14.8% | 13 | +1 | $198 | $64,685 | 6 | Videocine | false | false |
| 30 | 21 | Jonas Brothers: The 3D Concert Experience | $2,421 | -80.2% | 11 | -20 | $220 | $1,026,544 | 6 | Walt Disney Pictures | false | false |
| 31 | 40 | Backyard | $2,249 | +51.8% | 2 | -7 | $1,124 | $822,960 | 8 | Paramount Pictures International | false | false |
| 32 | 25 | Elegy | $1,776 | -73.7% | 7 | -6 | $253 | $161,558 | 5 | Corazón Films | false | false |
| 33 | 26 | Blind Dating 2009 Re-release | $1,372 | -77.9% | 3 | -10 | $457 | $111,261 | 8 | Quality Films | false | false |
| 34 | 41 | Dark Matter | $1,313 | -2.7% | 2 | -3 | $656 | $16,443 | 3 | David Distribucion | false | false |
| 35 | 27 | Desierto adentro | $1,305 | -78.2% | 4 | -10 | $326 | $41,403 | 5 | Gussi Films | false | false |
| 36 | 31 | Watchmen | $1,253 | -74.4% | 4 | -15 | $313 | $2,292,799 | 6 | Paramount Pictures International | false | false |
| 37 | 35 | Standard Operating Procedure | $911 | -69.2% | 2 | -5 | $455 | $6,213 | 2 | N/A | false | false |
| 38 | 32 | Last Chance Harvey | $722 | -83.6% | 2 | -8 | $361 | $264,672 | 4 | Gussi Films | false | false |
| 39 | 37 | To Love | $613 | -72.8% | 2 | -15 | $306 | $606,618 | 7 | Gussi Films | false | false |
| 40 | 47 | Role Models | $555 | +113.5% | 4 | +3 | $138 | $316,587 | 8 | Universal Pictures International (UPI) | false | false |
