| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Monsters vs. Aliens | $201,337 | -30% | 71 | -8 | $2,835 | $535,707 | 2 | United International Pictures | false | false |
| 2 | - | Dragonball Evolution | $190,116 | - | 57 | - | $3,335 | $194,059 | 1 | 20th Century Fox International | true | false |
| 3 | - | Race to Witch Mountain | $181,630 | - | 36 | - | $5,045 | $181,630 | 1 | Walt Disney Pictures | true | false |
| 4 | 2 | Underworld: Rise of the Lycans | $39,996 | -32.1% | 30 | - | $1,333 | $275,918 | 4 | Sony Pictures Releasing | false | false |
| 5 | 4 | Gran Torino | $37,862 | -12.4% | 10 | -3 | $3,786 | $228,998 | 4 | Warner Bros. | false | false |
| 6 | 5 | Slumdog Millionaire | $33,353 | -11% | 15 | -3 | $2,223 | $665,775 | 8 | Bazuca Films | false | false |
| 7 | 3 | Bedtime Stories | $23,764 | -51.1% | 30 | -5 | $792 | $1,007,650 | 8 | Walt Disney Pictures | false | false |
| 8 | 6 | Changeling | $17,603 | -39.9% | 15 | -18 | $1,173 | $232,849 | 5 | United International Pictures | false | false |
| 9 | 7 | Confessions of a Shopaholic | $15,969 | -44.7% | 14 | -7 | $1,140 | $86,511 | 3 | Walt Disney Pictures | false | false |
| 10 | 8 | Reincarnation 2009 Re-release | $14,933 | -13.9% | 7 | - | $2,133 | $53,758 | 3 | Andes Films | false | false |
| 11 | - | Sex Drive | $14,206 | - | 11 | - | $1,291 | $14,206 | 1 | N/A | true | false |
| 12 | 9 | He's Just Not That Into You | $7,743 | -26.7% | 3 | -6 | $2,581 | $264,252 | 9 | Warner Bros. | false | false |
| 13 | 10 | Milk | $6,751 | -31.9% | 4 | -2 | $1,687 | $32,258 | 3 | United International Pictures | false | false |
| 14 | 13 | Doubt | $6,307 | -15.9% | 6 | - | $1,051 | $126,450 | 7 | Walt Disney Pictures | false | false |
| 15 | 12 | Friday the 13th | $3,335 | -56.3% | 5 | -6 | $667 | $268,707 | 9 | United International Pictures | false | false |
| 16 | - | My Brother is an Only Child | $3,015 | - | 1 | - | $3,015 | $3,015 | 1 | Transeuropa | true | false |
| 17 | 11 | Valkyrie | $2,124 | -72.4% | 3 | -4 | $708 | $786,830 | 9 | 20th Century Fox International | false | false |
| 18 | 15 | The Curious Case of Benjamin Button | $1,592 | -71.8% | 3 | -3 | $530 | $1,108,703 | 12 | Warner Bros. | false | false |
| 19 | 18 | Righteous Kill | $1,448 | -58.5% | 1 | -3 | $1,448 | $75,329 | 6 | CDI Films | false | false |
| 20 | 20 | The Duchess | $1,445 | -49.8% | 1 | - | $1,445 | $73,434 | 8 | United International Pictures | false | false |
| 21 | 14 | Impy's Island | $1,257 | -78.4% | 4 | -11 | $314 | $117,488 | 6 | Bazuca Films | false | false |
| 22 | 22 | Descendents | $990 | -47.5% | 4 | -3 | $247 | $29,595 | 4 | N/A | false | false |
| 23 | 16 | Watchmen | $910 | -83.5% | 3 | -9 | $303 | $214,235 | 6 | United International Pictures | false | false |
| 24 | 28 | Jonas Brothers: The 3D Concert Experience | $849 | +20.3% | 2 | +1 | $424 | $126,592 | 6 | Walt Disney Pictures | false | false |
| 25 | 19 | Frost/Nixon | $723 | -76% | 1 | -1 | $723 | $4,716 | 2 | United International Pictures | false | false |
| 26 | 24 | Flawless | $607 | -40.7% | 1 | - | $607 | $25,274 | 7 | Bazuca Films | false | false |
| 27 | 25 | Seven Pounds | $578 | -42.8% | 2 | -1 | $289 | $95,209 | 8 | Sony Pictures Releasing | false | false |
| 28 | 17 | Planet Terror | $511 | -89.1% | 3 | -3 | $170 | $16,907 | 3 | Bazuca Films | false | false |
