| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Fast & Furious | $3,543,145 | - | 654 | - | $5,417 | $3,543,145 | 1 | Universal Pictures International (UPI) | true | false |
| 2 | - | Monsters vs. Aliens | $2,050,337 | - | 753 | - | $2,722 | $3,045,607 | 1 | Paramount Pictures International | true | false |
| 3 | 1 | Another Egg and Chicken Movie | $724,509 | -48.4% | 446 | +7 | $1,624 | $6,307,682 | 3 | Videocine | false | false |
| 4 | 2 | Knowing | $521,187 | -31.8% | 316 | -1 | $1,649 | $1,860,111 | 2 | Corazón Films | false | false |
| 5 | 3 | Race to Witch Mountain | $420,738 | -39.1% | 243 | -117 | $1,731 | $1,485,309 | 2 | Walt Disney Pictures | false | false |
| 6 | - | The Accidental Husband | $281,438 | - | 250 | - | $1,125 | $302,302 | 1 | Walt Disney Pictures | true | false |
| 7 | 6 | Gran Torino | $216,301 | -28.5% | 183 | -18 | $1,181 | $752,655 | 2 | Warner Bros. | false | false |
| 8 | - | The Reader | $178,438 | - | 99 | - | $1,802 | $182,577 | 1 | Gussi Films | true | false |
| 9 | 5 | The Unborn | $176,052 | -53% | 227 | -109 | $775 | $4,488,688 | 4 | Universal Pictures International (UPI) | false | false |
| 10 | 7 | Slumdog Millionaire | $154,464 | -13.3% | 131 | -46 | $1,179 | $4,980,145 | 7 | Gussi Films | false | false |
| 11 | 8 | He's Just Not That Into You | $88,179 | -40.1% | 109 | -36 | $808 | $1,728,993 | 5 | Gussi Films | false | false |
| 12 | 12 | Changeling | $82,669 | +32.1% | 94 | +11 | $879 | $1,678,742 | 6 | Universal Pictures International (UPI) | false | false |
| 13 | 9 | Paul Blart: Mall Cop | $62,135 | -57.6% | 110 | -137 | $564 | $1,757,656 | 4 | Sony Pictures Releasing | false | false |
| 14 | 32 | Milk | $41,197 | +316.8% | 56 | +44 | $735 | $468,961 | 5 | Universal Pictures International (UPI) | false | false |
| 15 | 14 | Transporter 3 | $25,212 | -53% | 44 | -32 | $573 | $541,944 | 7 | Zima Entertainment | false | false |
| 16 | 18 | Doubt | $25,081 | -33.8% | 34 | -16 | $737 | $767,993 | 7 | Walt Disney Pictures | false | false |
| 17 | 10 | The International | $24,768 | -71.2% | 31 | -111 | $798 | $471,229 | 3 | Sony Pictures Releasing | false | false |
| 18 | 19 | Righteous Kill | $17,226 | -48.9% | 25 | -21 | $689 | $1,033,290 | 9 | Corazón Films | false | false |
| 19 | 11 | Underworld: Rise of the Lycans | $17,220 | -74.2% | 39 | -93 | $441 | $3,811,302 | 9 | Sony Pictures Releasing | false | false |
| 20 | 13 | Big Stan | $13,558 | -76.5% | 20 | -50 | $677 | $1,938,133 | 9 | Videocine | false | false |
| 21 | 67 | Jonas Brothers: The 3D Concert Experience | $12,243 | +604.4% | 31 | +22 | $394 | $1,013,021 | 5 | Walt Disney Pictures | false | false |
| 22 | 24 | The Wrestler | $11,798 | -32.3% | 23 | -16 | $512 | $462,790 | 6 | Corazón Films | false | false |
| 23 | 17 | The Pink Panther 2 | $11,514 | -71.4% | 44 | -70 | $261 | $2,153,572 | 6 | Sony Pictures Releasing | false | false |
| 24 | 27 | Rachel Getting Married | $8,032 | -39.5% | 8 | -2 | $1,004 | $58,101 | 3 | Sony Pictures Releasing | false | false |
| 25 | 35 | Elegy | $6,755 | -11.9% | 13 | -4 | $519 | $154,066 | 4 | Corazón Films | false | false |
| 26 | 26 | Blind Dating 2009 Re-release | $6,198 | -58.5% | 13 | -13 | $476 | $105,025 | 7 | Quality Films | false | false |
| 27 | 101 | Desierto adentro | $5,981 | +1,669.5% | 14 | +13 | $427 | $35,585 | 4 | Gussi Films | false | false |
| 28 | 22 | My Sassy Girl | $5,958 | -71.5% | 20 | -29 | $297 | $383,082 | 6 | Videocine | false | false |
| 29 | 61 | In Bruges | $5,161 | +116.2% | 14 | +4 | $368 | $63,440 | 3 | Corazón Films | false | false |
| 30 | 40 | The Spirit | $4,942 | -26% | 16 | -4 | $308 | $454,514 | 11 | Sony Pictures Releasing | false | false |
| 31 | 16 | Watchmen | $4,901 | -88.7% | 19 | -105 | $257 | $2,286,321 | 5 | Paramount Pictures International | false | false |
| 32 | 15 | Last Chance Harvey | $4,414 | -90.7% | 10 | -48 | $441 | $260,737 | 3 | Gussi Films | false | false |
| 33 | 31 | The Secret Life of Bees | $3,714 | -67.5% | 16 | -16 | $232 | $98,939 | 4 | 20th Century Fox International | false | false |
| 34 | 25 | Right at Your Door 2009 Re-release | $3,575 | -78.7% | 7 | -23 | $510 | $36,530 | 2 | Gussi Films | false | false |
| 35 | - | Standard Operating Procedure | $2,959 | - | 7 | - | $422 | $2,959 | 1 | N/A | true | false |
| 36 | 33 | All the Boys Love Mandy Lane | $2,470 | -71.8% | 10 | -8 | $247 | $75,989 | 5 | Zima Entertainment | false | false |
| 37 | 21 | To Love | $2,251 | -90% | 17 | -80 | $132 | $603,703 | 6 | Gussi Films | false | false |
| 38 | 38 | Fierce People | $2,247 | -68.9% | 12 | -20 | $187 | $59,080 | 5 | Videocine | false | false |
| 39 | 36 | Timecrimes | $1,918 | -74.2% | 10 | -17 | $191 | $124,152 | 9 | David Distribucion | false | false |
| 40 | 48 | Backyard | $1,482 | -65.9% | 9 | -21 | $164 | $818,074 | 7 | Paramount Pictures International | false | false |
| 41 | 39 | Dark Matter | $1,349 | -80.5% | 5 | -8 | $269 | $13,910 | 2 | David Distribucion | false | false |
| 42 | 37 | Friday the 13th | $886 | -88.1% | 7 | -19 | $126 | $780,380 | 8 | Sony Pictures Releasing | false | false |
| 43 | 28 | Confessions of a Shopaholic | $786 | -93.6% | 1 | -22 | $786 | $1,126,919 | 8 | Walt Disney Pictures | false | false |
| 44 | 55 | Agent Macaw: Shaken & Stirred | $487 | -83.2% | 12 | -10 | $40 | $1,518,150 | 8 | Videocine | false | false |
| 45 | 80 | Valkyrie | $439 | -58% | 1 | -3 | $439 | $4,592,143 | 8 | 20th Century Fox International | false | false |
| 46 | 78 | My Bloody Valentine | $293 | -76.2% | 2 | -6 | $146 | $1,838,594 | 8 | Gussi Films | false | false |
| 47 | 45 | Role Models | $260 | -94.6% | 1 | -10 | $260 | $315,858 | 7 | Universal Pictures International (UPI) | false | false |
